Bioinformatic Identification of Neuroblastoma Microenvironment-Associated Biomarkers with Prognostic Value
Table 4
The Cox analysis on prognostic genes and MYCN in the GSE49710 cohort.
Variable
Univariate Cox analysis
Multivariate Cox analysis
Coef
HR (95% CI)
z
value
Coef
HR (95% CI)
z
value
ABCA6
−0.345
0.708 (0.651–0.77)
−8.1
5.38E − 16
0.0186
1.02 (0.776–1.34)
0.134
0.894
SEPP1
−0.392
0.676 (0.602–0.759)
−6.64
3.11E − 11
−0.0928
0.911 (0.644–1.29)
−0.524
0.6
SLAMF8
−0.505
0.603 (0.537–0.677)
−8.54
1.29E − 17
−0.274
0.76 (0.586–0.986)
−2.07
0.0389
GPR171
−0.415
0.66 (0.582–0.749)
−6.44
1.21E − 10
−0.108
0.898 (0.581–1.39)
−0.484
0.629
ABCA9
−0.387
0.679 (0.613–0.753)
−7.34
2.10E − 13
−0.303
0.738 (0.574–0.95)
−2.36
0.0183
ARHGAP15
−0.393
0.675 (0.598–0.763)
−6.31
2.77E − 10
0.583
1.79 (1.22–2.62)
3
0.00272
IL7R
−0.375
0.687 (0.617–0.765)
−6.86
7.05E − 12
−0.112
0.894 (0.624–1.28)
−0.607
0.544
HLA-DPB1
−0.403
0.668 (0.588–0.759)
−6.21
5.40E − 10
0.0422
1.04 (0.735–1.48)
0.236
0.813
GZMA
−0.305
0.737 (0.666–0.816)
−5.86
4.62E − 09
0.216
1.24 (0.993–1.55)
1.89
0.0581
GPR183
−0.387
0.679 (0.604–0.763)
−6.51
7.63E − 11
−0.0716
0.931 (0.746–1.16)
−0.633
0.527
CCL19
−0.184
0.832 (0.783–0.884)
−5.94
2.81E − 09
0.147
1.16 (1.01–1.33)
2.09
0.0362
ITK
−0.35
0.705 (0.641–0.775)
−7.25
4.04E − 13
−0.125
0.883 (0.662–1.18)
−0.85
0.395
FGL2
−0.383
0.682 (0.612–0.76)
−6.95
3.66E − 12
0.0172
1.02 (0.677–1.53)
0.0827
0.934
CD1C
−0.356
0.701 (0.64–0.767)
−7.68
1.65E − 14
−0.235
0.791 (0.633–0.989)
−2.06
0.0393
MYCN amplification
2.05
7.8 (5.26–11.5)
10.2
1.19E − 24
1.7
5.45 (3.22–9.21)
6.33
2.48E − 10
Concordance = 0.809 (se = 0.022), likelihood ratio test = 129.7 on 15 df, ≤ 2e − 16; Wald test = 139.2 on 15 df, ≤ 2e – 16; score (log-rank) test = 186.3 on 15 df, ≤ 2e − 16.
