Gene Expression, Network Analysis, and Drug Discovery of Neurofibromatosis Type 2-Associated Vestibular Schwannomas Based on Bioinformatics Analysis

Table 3

28 hub genes with connectivity degree ≥20.

Number	Gene	Degree of connectivity	Regulation
1	EGFR	59	Down
2	IL1B	53	Up
3	PIK3CG	49	Up
4	CSF1R	40	Up
5	CXCL12	39	Down
6	CD34	36	Down
7	EDN1	36	Down
8	ITGAX	34	Up
9	ACACB	34	Down
10	LYN	32	Up
11	FCGR3A	32	Up
12	DCN	30	Down
13	CD36	30	Down
14	VWF	30	Down
15	CD86	29	Up
16	TLR2	29	Up
17	ACTA2	29	Down
18	LEP	29	Down
19	FCGR3B	26	Up
20	NCAM1	25	Up
21	CAV1	24	Down
22	HBA1	23	Up
23	ACTG2	22	Down
24	SPP1	21	Up
25	C3	21	Up
26	PDGFRA	20	Down
27	CCND1	20	Up
28	RRAS2	20	Up