Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer

Table 1

Investigation of mutation count characteristics in metastatic colorectal cancer database (MSKCC, Cancer Cell 2018). Significant values are marked in bold.

Parameters	Test for mutation	value for mutation count	Corrected value for mutation count
Age at diagnosis	Spearman	value <0.05	value <0.05
Sex	Mann–Whitney	value >0.05	value >0.1
First site of metastasis	Kruskal–Wallis	value >0.05	value >0.1
Fraction of genome altered	Spearman	value <0.05	value <0.1
Tumor sample histology	Mann–Whitney	value <0.05	value <0.05
Stage at diagnosis	Kruskal–Wallis	value <0.05	value <0.05
Primary tumor location	Mann–Whitney	value <0.05	value <0.05
Primary tumor site	Kruskal–Wallis	value <0.05	value <0.05
MSI score	Spearman	value <0.05	value <0.05
BRCA mutations	Mann–Whitney	value <0.05	value <0.05
Additional analyses
BRCA mutations and tumor sample histology	Chi-square	value <0.05	value <0.05
Stratified mutation count analysis
BRCA mutations among MC	Mann–Whitney	value <0.05	value <0.05
BRCA mutations among AC	Mann–Whitney	value <0.05	value <0.05
Tumor sample histology and BRCA mutations	Mann–Whitney	value <0.05	value <0.05
Tumor sample histology and BRCA WT	Mann–Whitney	value <0.05	value <0.05

Threshold for significance after correction for multiple hypotheses was 0.1.