Patterns and Prevalence of Germline BRCA1 and BRCA2 Mutations among High-Risk Breast Cancer Patients in Jordan: A Study of 500 Patients

Table 2

Rates of positive BRCA1 and BRCA2 mutation across different indications.

Variable		Total	Positive mutations
			BRCA1	BRCA2	BRCA1 and BRCA2	value
Age at diagnosis (years)	≤40	333	15 (4.5%)	29 (8.7%)	44 (13.2%)	0.530
	>40	184	9 (4.9%)	19 (10.3%)	28 (15.2%)
Age ≤ 50 years with one or more close relatives with breast cancer at any age	Yes	242	8 (3.3%)	32 (13.2%)	40 (16.5%)	0.1
	No	275	16 (5.8%)	16 (5.8%)	32 (11.6%)
Age ≤ 60 with triple-negative disease	Yes	57	16 (28.1%)	4 (7.0%)	19 (35.1%)	<0.001
	No	460	8 (1.7%)	44 (9.6%)	53 (11.5%)
Any age with at least 2 breast cancer primaries	Yes	57	4 (7.0%)	4 (7.0%)	8 (14.0%)	0.98
	No	460	20 (4.3%)	44 (9.6%)	64 (13.9%)
Any age with 2 or more close relatives with breast cancer	Yes	115	7 (6.1%)	21 (18.3%)	28 (24.3%)	<0.001
	No	402	17 (4.2%)	27 (6.7%)	44 (10.9%)
Any age with one or more close relatives with invasive ovarian cancer diagnosed at any age	Yes	19	2 (10.5%)	4 (21.1%)	6 (31.6%)	0.023
	No	498	22 (4.4%)	44 (8.8%)	66 (13.3%)
All patients		517	24 (4.6%)	48 (9.3%)	72 (13.9%)

value comparing risk factor categories.