ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m<sup>6</sup>A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity

<div>ZC3H13 displays low expression in HCC and correlates with survival outcomes. (a) Expression of ZC3H13 in 369 HCC and 160 control tissue specimens from TCGA and GTEx projects. (b) RT-qPCR examining the mRNA expression of ZC3H13 in 30 paired HCC as well as adjacent control tissue specimens in our cohort. (c, d) Western blotting detecting the protein expression of ZC3H13 in three HCC as well as adjacent control tissue specimens. (e) RT-qPCR testing the mRNA expressions of ZC3H13 in human normal liver cells L-O2 as well as human liver cancer cell lines HUH-7, Hep3B, HepG2, and SMMC-7721. 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Journal of Oncology

fig1

Figure 1

Figure 1: ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m<sup>6</sup>A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity 

Journal of Oncology

ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m6A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity

Figure 1

ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m⁶A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity