Research Article
Identification of Latent Diagnostic Biomarkers and Biological Pathways in Dermatomyositis Based on WGCNA
Table 1
Top 5 MCODE pathway and process enrichment analysis for each group.
| | MCODE | GO | Description | Log10 () |
| | MCODE 1 | R-HSA-195258 | RHO GTPase effectors | −12.0 | | MCODE 1 | R-HSA-9664422 | FCGR3A-mediated phagocytosis | −10.4 | | MCODE 1 | R-HSA-9664417 | Leishmania phagocytosis | −10.4 | | MCODE 2 | R-HSA-72163 | mRNA splicing—major pathway | −11.4 | | MCODE 2 | R-HSA-72172 | mRNA splicing | −11.3 | | MCODE 2 | R-HSA-72203 | Processing of capped intron-containing pre-mRNA | −10.4 | | MCODE 3 | GO:0040029 | Regulation of gene expression, epigenetic | −6.1 | | MCODE 3 | GO:0051052 | Regulation of the DNA metabolic process | −6.0 | | MCODE 3 | GO:0034728 | Nucleosome organization | −5.8 | | MCODE 4 | R-HSA-909733 | Interferon alpha/beta-signalling | −37.1 | | MCODE 4 | R-HSA-913531 | Interferon signalling | −30.3 | | MCODE 4 | R-HSA-1280215 | Cytokine signalling in the immune system | −22.4 | | MCODE 5 | R-HSA-5696395 | Formation of incision complex in GG-NER | −10.9 | | MCODE 5 | R-HSA-5696399 | Global genome nucleotide excision repair (GG-NER) | −9.4 | | MCODE 5 | R-HSA-5696398 | Nucleotide excision repair | −8.8 |
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