circDENND4C Promotes Proliferation and Metastasis of Lung Cancer by Upregulating BRD4 Signaling Pathway

Figure 6

circDENND4C promotes the proliferation and metastasis of NSCLC cells through miR-141-3p/BRD4. (a) Detection of circDENND4C overexpression transfection efficiency. (b) Detection of transfection efficiency of siRNA BRD4. (c) The CCK-8 function recovery experiment was used to verify the cell proliferation ability of circDENND4C + si-BRD4 and circDENND4C + miR-141-3p group and circDENND4C group. (d) The Transwell function recovery experiment was used to verify the cell invasion ability of circDENND4C + si-BRD4 and circDENND4C + miR-141-3p group and circDENND4C group. (e) The clone formation function recovery experiment was used to verify the cell clone formation ability of circDENND4C + si-BRD4 and circDENND4C + miR-141-3p group and circDENND4C group. (f) The schematic diagram was used to clarify the potential molecular mechanism of circDENND4C through sponge adsorption of miR-141-3p, promoting the transfer and proliferation of NSCLC, and indirectly upregulating BRD4. ^∗P < 0.05 and ^∗∗P < 0.01.