Lumpectomy Combined with Adjuvant Radiotherapy Could Be a Treatment Option for Primary Squamous Cell Carcinoma of the Breast

Table 2

Univariate analysis of breast cancer-specific survival and overall survival.

Characteristics	BCSS			OS
	HR	95% CI	p	HR	95% CI	p
Age (years)
≤50	1			1
>50	1.38	0.81–2.36	0.23	3.39	2.16–5.31	<0.001
Race
Others	1			1
White	0.64	0.40–1.02	0.061	0.98	0.69–1.39	0.92
Stage
I	1			1
II	3.19	1.36–7.49	0.0079	1.47	1.01–2.16	0.046
III	11.63	4.93–27.44	<0.001	3.90	2.58–5.88	<0.001
Tumor stage
T1	1			1
T2	2.08	1.03–4.20	0.041	1.26	0.87–1.82	0.22
T3	4.19	1.98–8.45	0.0002	2.30	1.51–3.51	<0.001
T4	9.02	4.29–18.95	<0.001	4.31	2.78–6.68	<0.001
Nodal status
N0	1			1
N1	2.89	1.79–4.66	<0.001	1.53	1.07–2.19	0.019
N2-3	4.41	2.46–7.90	<0.001	2.98	1.94–4.57	<0.001
ER status
Negative	1			1
Positive	1.27	0.74–2.18	0.39	1.05	0.72–1.55	0.79
PR status
Negative	1			1
Positive	0.48	0.19–1.19	0.11	0.48	0.27–0.87	0.015
Grade
Well-differentiated	1			1
Moderately differentiated	1.08	0.48–2.42	0.85	0.97	0.61–1.53	0.89
Poor or undifferentiated	1.30	0.62–2.73	0.49	0.84	0.54–1.29	0.42
Chemotherapy
No/unknown	1			1
Yes	1.19	0.81–1.75	0.38	0.54	0.41–0.71	<0.001
Treatment
LUMP only	1			1
LUMP + RT	0.29	0.11–0.75	0.01	0.48	0.30–0.77	0.0023
MAST only	1.35	0.78–2.35	0.28	1.28	0.91–1.81	0.15
MAST + RT	1.51	0.79–2.90	0.21	0.91	0.58–1.43	0.67

MAST, mastectomy; LUMP, lumpectomy; RT, radiotherapy; ER, estrogen receptor; PR, progesterone receptor; BCSS, breast cancer-specific survival; OS, overall survival.