MicroRNAs as Biomarkers for Early Diagnosis, Prognosis, and Therapeutic Targeting of Ovarian Cancer

Table 1

Targets and functions of important miRNAs associated with ovarian cancer.

miRNA	Target	Alteration	Cellular function	Ref.
miR-214	Sema 4D (Semaphoring 4D)	Upregulation	Inhibits cell proliferation and promotes apoptosis	[137]
	LHX6 (LIM Homeobox 6)	Downregulation	Induces apoptosis	[138]
	PETN (phosphatase and tensin homolog)	Upregulation	Promotes radioresistance	[139]
miR-182	BNIP3 (BCL2 interacting protein 3)	Upregulation	Inhibits proliferation and migration	[140]
miR-23b	CCNG1 (cyclin G1)	Upregulation	Inhibits ovarian cancer tumorigenesis and progression	[141]
miR-381	YY1 (the ubiquitous transcription factor yin yang 1)	Upregulation	Inhibits ovarian cancer cell proliferation, migration, and invasion	[142]
miR-132	E2F5 (transcription factor)	Upregulation	Inhibits cell migration and invasion of cancer cells	[143]
miR-143-3p	TAK1 (transforming growth factor-β-activated kinase 1)	Upregulation	Inhibits the proliferation, migration, and invasion of ovarian cancer cells	[144]
	CTGF (connective tissue growth factor)	Upregulation	Inhibits ovarian cancer cells proliferation, migration, and invasion	[145]
miR-145	CCND2 & E2F3 (cyclin D2)	Upregulation	The invasion and proliferation suppressor	[146]
miR-34a-5p	NEAT1 (nuclear paraspeckle assembly transcript 1)	Downregulation	Suppresses Cell proliferation and triggers apoptosis	[147]
miR-383-5p	TRIM27 (tripartite motif containing 27)	Upregulation	Proliferation, chemosensitivity suppressor and enhancer in ovarian cancer cells	[148]
miR-148a-3p	c-Met (tyrosine-protein kinase Met)	Upregulation	Inhibits invasion of ovarian cancer cells and cell migration	[149]
miR-141	KEAP1 (Kelch-like ECH-associated protein 1)	Upregulated	Cisplatin resistance	[150]
miR-218	RUNX2 (runt-related transcription factor 2)	Upregulated	Inhibits proliferation and invasion	[151]
miR-199a	HIF-1α & HIF-2α (hypoxia-inducible factor)	Upregulation	Decreases migration and metastatic tumor formation	[152]
miR-491-5p	EGFR (epidermal growth factor receptor) and BCL-XL	Upregulation	Induces cancer cell apoptosis by blocking downstream AKT and MAPK signaling pathways	[153]
miR-744-5p	HNRNPC (heterogeneous nuclear ribonucleoproteins C1/C2) and NFIX (nuclear factor 1 X-type)	Upregulation	Induces tumor cell apoptosis	[154]