The Potential Therapeutic Role of Mesenchymal Stem Cells-Derived Exosomes in Osteoradionecrosis

Table 2

The expression of partial miRNA derived from exosomes and the effects on osteogenesis.

mi-RNA	Expression level	Function
miR-29a	Carried in MSC exosomes	Induce the osteogenic differentiation of MSCs [147]
miR-29c
miR-206	The expression of osteoblast-related miRNA was significantly increased [147]	Promote the proliferation and differentiation of OB [147]
miR-27a
miR-196a		Stimulate the differentiation of BMSCs into osteoblasts [148]
miR-218	Significantly upregulated in exosomes isolated from BMSCs culture [149]	Stimulate the differentiation of BMSCs into osteoblasts [148]
miR-199b-5p		Promote chondrogenic differentiation [150]
miR-148a-3p		Prevent the osteonecrosis of the femoral head by inhibiting SMURF1 [151]
miR-135b		Enhance chondrocyte proliferation by downregulating SP1 [152]
miR-221	Significantly lower expressed in individual exosomal samples over time [149]	Inhibit osteogenic differentiation of BMSCs via the IGF-1/ERK pathway [153]
miR-155		Suppress osteoblastic differentiation by targeting SIRT1 [154]
miR-181a-3p		Inhibit osteogenic differentiation of MCSs by targeting BMP10 [155]
miR-320c		Reduce the osteogenic potential of BMSCs through Runx2 [156]
miR-885-5p		Exert a negative regulatory effect on the osteogenic differentiation of BMSCs by inhibiting Runx2 [149]
miR-92a-3p	Reduced in the OA chondrocyte-secreted exosome [157]	Promote chondrogenesis and suppress cartilage degradation [157]
miR-140-5p	Derived from miR-140-5p-overexpressing synovial mesenchymal stem cells [158]	Enhance proliferation and migration of chondrocytes through the Wnt signaling pathway [158]