Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions

Figure 3

The signaling pathway associated with lncRNA UCA1 in GI cancer. LncRNA UCA1 induces EMT by regulating EMT key proteins. It also promotes the activation of PI3K/Akt/mTOR signaling pathway, ERK/MMP9 signaling pathway, ERK signaling pathway, Hippo pathway, WISP2/β-catenin signaling pathway, and MAPKAPK2/HSP27 signaling pathway by regulating their key proteins. Additionally, lncRNA UCA1 also interacts with EZH2 to regulate protein expression.