Plasma-Derived Exosomal microRNA-130a Serves as a Noninvasive Biomarker for Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

Table 5

Univariate and multivariate analyses of recurrence-free survival in 184 patients with OSCC.

Variable	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Exosomal miR-130a (high)	3.518 (1.917–6.455)	<0.001	2.627 (1.382–4.993)	0.003
Age (≥60 years)	1.181 (0.66–2.114)	0.575
Gender (male)	1.121 (0.603–2.082)	0.718
Smoking habit (yes)	1.41 (0.786–2.527)	0.249
Drinking habit (yes)	1.051 (0.549–2.014)	0.88
Tumor site (tongue)	1.072 (0.59–1.948)	0.819
T-stage (T3 + T4)	2.357 (1.287–4.317)	0.005	2.086 (1.082–4.023)	0.028
N-stage (positive)	1.64 (0.913–2.946)	0.098
TNM stage (III-IV)	2.429 (1.336–4.414)	0.004	2.056 (1.073–3.936)	0.03
Histologic grade (poor)	2.583 (1.38–4.836)	0.003	2.007 (1.023–3.938)	0.043

HR: hazard ratio; CI: confidence interval; mean value<0.05.