Research Article
GJA1 rs2071165 A > G Variant Increased Gastric Cancer Risk in Females of Northwest China: A Case-Control Study
Table 1
Genetic variants associated with the susceptibility of gastric cancer.
| Model | Genotype | Control | Case | OR2 (95% CI) | | OR (95% CI) | 1 |
| rs2071165 | HWE3 | Codominant | GG | 423 | 382 | 1.00 | 0.99 | 1.00 | 0.96 | AG | 288 | 257 | 0.98 (0.79–1.22) | 1.03 (0.82–1.30) | AA | 45 | 41 | 1.01 (0.64–1.57) | 1.03 (0.65–1.64) |
| Dominant | GG | 423 | 382 | 1.00 | 0.89 | 1.00 | 0.77 | AG-AA | 333 | 298 | 0.99 (0.80–1.21) | 1.03 (0.83–1.29) |
| rs4530741 | HWE | Codominant | CC | 250 | 228 | 1.00 | 0.43 | 1.00 | 0.33 | AC | 351 | 330 | 1.03 (0.82–1.30) | 1.04 (0.81–1.32) | AA | 156 | 122 | 0.86 (0.64–1.15) | 0.83 (0.61–1.14) |
| Dominant | CC | 250 | 228 | 1.00 | 0.84 | 1.00 | 0.81 | AC-AA | 507 | 452 | 0.98 (0.78–1.22) | 0.97 (0.77–1.22) |
| rs6874309 | HWE | Codominant | AA | 635 | 571 | 1.00 | 0.6 | 1.00 | 0.78 | AT | 114 | 106 | 1.03 (0.78–1.38) | 0.96 (0.71–1.30) | TT | 8 | 4 | 0.56 (0.17–1.86) | 0.65 (0.18–2.37) |
| Dominant | AA | 635 | 571 | 1.00 | 0.98 | 1.00 | 0.7 | AT-TT | 122 | 110 | 1.00 (0.76–1.33) | 0.94 (0.70–1.27) |
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1Adjust by age and gender. 2Odds ratio. 3Hardy–Weinberg equilibrium.
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