Exploration of the Key Proteins in the Normal-Adenoma-Carcinoma Sequence of Colorectal Cancer Evolution Using In-Depth Quantitative Proteomics

Table 1

Univariate and multivariate analysis of 59 CRC patients.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
Sex
Female	Reference
Male	1.023	0.494–2.120	0.951
Age
<65	Reference			Reference
≥65	2.084	0.948–4.583	0.068	1.554	0.666–3.626	0.308
Histological subtype
Adenocarcinoma	Reference			Reference
MUC + SRCC	4.069	1.784–9.281	0.001	2.819	0.941–8.444	0.064
T stage
1 + 2	Reference
3	0.998	0.363–2.479	0.997
4	2.172	0.725–6.508	0.166
N status
−	Reference			Reference
+	1.974	0.917–4.253	0.082	1.811	0.784–4.179	0.164
Tumor location
Right	Reference			Reference
Left	0.409	0.166–1.007	0.052	0.415	0.147–1.167	0.095
VI
−	Reference			Reference
+	7.051	3.306–15.037	<0.001	2.076	0.734–5.866	0.168
RRP12 expression
Low	Reference
High	1.609	0.759–3.414	0.215
SERPINH1 expression
Low	Reference			Reference
High	4.806	2.161–10.091	<0.001	3.086	1.148–8.297	0.026

HR: hazard ratio; 95% CI: 95% confidence interval; MUC: mucinous adenocarcinoma; SRCC: signet ring cell carcinoma; VI: vascular invasion.