Research Article
Association of HER1 and HER2 Gene Variants in the Predisposition of Colorectal Cancer
Table 2
HER1 and HER2 receptor SNPs’ genotype and allele frequencies in colorectal cancer cases and the control population.
| | SNP ID | Genotype | Controls, n (frequency) | Colorectal cancer, n (frequency) | OR (95% CI) | χ2 value | value |
| | rs763317 HER1 | AA | 43 (0.29) | 40 (0.29) | Ref | | | | GA | 82 (0.55) | 73 (0.52) | 0.957 (0.561–1.632) | 0.03 | 0.87181 | | GG | 24 (0.16) | 27 (0.19) | 1.209 (0.602–2.431) | 0.28 | 0.59350 | | Allele | | | | | | | A | 168 (0.56) | 153 (0.55) | Ref | | | | G | 130 (0.44) | 127 (0.45) | 1.073 (0.773–1.490) | 0.18 | 0.67521 |
| | rs3752651 HER1 | TT | 119 (0.73) | 102 (0.71) | Ref | | | | CT | 38 (0.23) | 41 (0.29) | 1.259 (0.752–2.106) | 0.77 | 0.38023 | | CC | 6 (0.04) | 0 (0) | 0.090 (0.005–1.611) | 5.03 | 0.02493 | | Allele | | | | | | | T | 276 (0.85) | 245 (0.86) | Ref | | | | C | 50 (0.15) | 41 (0.14) | 0.924 (0.591–1.445) | 0.12 | 0.72819 |
| | rs1058808 HER2 | GG | 62 (0.39) | 44 (0.32) | Ref | | | | CG | 81 (0.51) | 71 (0.51) | 1.235 (0.749–2.038) | 0.68 | 0.40828 | | CC | 17 (0.11) | 24 (0.17) | 1.989 (0.957–4.135) | 3.45 | 0.06333 | | Allele | | | | | | | G | 205 (0.64) | 159 (0.57) | Ref | | | | C | 115 (0.36) | 119 (0.43) | 1.334 (0.960–1.855) | 2.95 | 0.08608 |
| | rs1136201 HER2 | AA | 123 (0.76) | 120 (0.85) | Ref | | | | AG | 37 (0.23) | 21 (0.15) | 0.582 (0.322–1.051) | 3.26 | 0.07079 | | GG | 2 (0.01) | 0 (0) | 0.205 (0.010–4.314) | 1.94 | 0.16413 | | Allele | | | | | | | A | 283 (0.87) | 261 (0.93) | Ref | | | | G | 41 (0.13) | 21 (0.07) | 0.555 (0.320–0.965) | 4.45 | 0.03486 |
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OR 95% CI, odds ratio and 95% confidence interval. was considered significant and are depicted in bold. |
