Effect of the Number of Removed Lymph Nodes on Survival in Patients with FIGO Stage IB-IIA Cervical Squamous Cell Carcinoma following Open Radical Hysterectomy with Pelvic Lymphadenectomy: A Retrospective Cohort Study
Table 2
Cox proportional hazard analysis on prognostic factors related to survival in all the patients.
Variable
PFS
OS
Univariate
Multivariate 1
Multivariate 2
Univariate
Multivariate 1
Multivariate 2
value
HR
95% CI
value
HR
95% CI
value
value
HR
95% CI
value
HR
95% CI
value
Age, years
0.014
0.897
0.588–1.369
0.614
0.893
0.585–1.364
0.601
0.052
Menopausal status
0.004
1.223
0.800–1.870
0.353
1.229
0.803–1.880
0.342
0.008
1.255
0.904–1.743
0.174
1.258
0.906–1.747
0.171
FIGO stage
<0.001
1.450
1.123–1.873
0.004
1.450
1.122–1.872
0.004
<0.001
1.321
0.927–1.881
0.123
1.327
0.932–1.889
0.117
Tumor diameter (cm)
<0.001
1.425
1.118–1.816
0.004
1.425
1.118–1.816
0.004
<0.001
1.720
1.237–2.391
0.001
1.747
1.257–2.426
0.001
Depth of stromal invasion
<0.001
2.177
1.498–3.163
<0.001
2.176
1.497–3.162
<0.001
<0.001
4.145
2.133–8.058
<0.001
4.148
2.133–8.065
<0.001
LVSI
<0.001
2.122
1.610–2.798
<0.001
2.121
1.609–2.795
<0.001
<0.001
2.559
1.740–3.765
<0.001
2.556
1.737–3.761
<0.001
Parametrial invasion
<0.001
1.800
1.290–2.510
0.001
1.803
1.294–2.514
0.001
<0.001
1.689
1.069–2.670
0.025
1.697
1.075–2.680
0.023
Vaginal margin invasion
<0.001
2.025
1.366–3.002
<0.001
2.028
1.368–3.007
<0.001
<0.001
2.060
1.210–3.507
0.008
2.040
1.198–3.474
0.009
Lymph node metastasis
<0.001
1.963
1.507–2.555
<0.001
1.962
1.507–2.554
<0.001
<0.001
1.648
1.146–2.370
0.007
1.641
1.142–2.358
0.007
Adjuvant therapy
<0.001
0.522
0.389–0.699
<0.001
0.522
0.390–0.700
<0.001
<0.001
0.512
0.340–0.771
0.001
0.514
0.341–0.773
0.001
No. of RLN
0.183
1.075
0.859–1.344
0.528
0.194
1.236
0.833–1.834
0.292
No. of RLN (continuous)
0.218
1.005
0.991–1.019
0.523
0.420
1.002
0.981–1.024
0.853
FIGO, Federation of Gynecology and Obstetrics; LVSI, lymph-vascular space invasion; RLN, removed lymph nodes.
