E2F1 Maintains Gastric Cancer Stemness Properties by Regulating Stemness-Associated Genes

Figure 4

E2F1 regulates 5-Fu sensitivity in GC. (a) Downregulation of E2F1 in 7901 sensitized GC cells to 5-Fu. (b) Upregulation of E2F1 reduced the sensitivity of GC cells to 5-Fu. (c) Downregulation of E2F1 increased 5-Fu-induced apoptosis in GC cells whereas upregulation of E2F1 decreased 5-Fu-induced apoptosis in GC cells. (d) Compared with patients with high expression of E2F1, patients with low expression of E2F1 have a better OS after receiving 5-Fu chemotherapy.

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