Chemerin-9 Attenuates Experimental Abdominal Aortic Aneurysm Formation in ApoE^−/− Mice

Figure 4

Effects of chemerin-9 on the morphological changes of the abdominal aorta in ApoE^−/− mice. (a) Histopathological analysis of representative abdominal aortas of the Sham group, AAA group and chemerin-9 group using HE staining (upper) and quantification (lower) of adventitia thickness (n = 6/group). The adventitial area is shown with black dotted lines. (b) Representative EVG staining images (upper) of elastin and semiquantitative analysis (lower) of elastic laminae deficiency in the medial layer of the aneurysm (n = 6/group). (c) Representative IHC staining images (upper) of SMCs and semiquantitative analysis (lower) of depleted medial smooth muscle in three groups (n = 6/group). The data are shown as mean ± SD. ; vs. the Sham group; vs. the AAA group.

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