MCT4 Promotes Tumor Malignancy in F98 Glioma Cells

Figure 5

Tumor growth and cell death in MCT4 overexpression and knockdown F98 VOGIM slices. (a) VOGIM slices implanted with con, MCT4, and MCT4^KD F98 cells (green) as well as MCT4 cells treated with 100 μM pCMBS or 150 μM Phl (green) and stained with PI (red) directly after and 48 h after tumor implantation and treatment. (b) Quantification of tumor growth in VOGIM slices was performed with Fiji. Data were normalized to con. Statistical analysis was performed by two-way ANOVA with Bonferroni posttest (; , mean ± SEM, n = 9). (c) Quantification of tumor death in VOGIM slices was performed with Fiji. Data were normalized to con. Statistical analysis was performed by two-way ANOVA with Bonferroni posttest (^ns, mean ± SEM, n = 9).

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