Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer

Figure 1

Immunohistochemistry for ALDH1 (a-d) and Notch1 (e-h) in subtypes of oral squamous cell carcinomas. The ALDH1 showed negative immunoexpression in the verrucous carcinoma (a) and the strong cytoplasmic immunoexpression of ALDH1 was observed in well-differentiated (b), in poorly differentiated (c), and in basaloid (d) oral squamous cell carcinomas. The membranous immunopositivity of Notch1 is illustrated in peripheral cells of the verrucous carcinoma (e) and the Notch1 cytoplasmic expression can be observed in well-differentiated (f), in poorly differentiated (g), and in basaloid (h) squamous cell carcinomas (immunohistochemistry: anti-ALDH1–a = 100x, b-c = 200x, d = 50x; anti-Notch1–e = 200x, f = 100x, g-h = 400x).

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