Research Article

Immune Score Predicts Outcomes of Gastric Cancer Patients Treated with Adjuvant Chemoradiotherapy

Table 1

Correlation between IS and clinical parameters.

VariablesImmunoscore value
LowMedianHigh
n = 20n = 57n = 24
(19.8%)(56.4%)(23.8%)

Sex
Male15(21.4%)39(55.7%)16(22.9%)0.876
Female5(16.1%)18(58.1%)8(25.8%)

Age0.311
<6511(17.7%)33(53.2%)18(29.0%)
≥659(23.1%)24(61.5%)6(15.4%)

ECOG0.433
013(21.0%)32(51.6%)17(27.4%)
17(17.9%)25(64.1%)7(17.9%)

LDH (U/L)0.999
<25018(20.2%)50(56.2%)21(23.6%)
≥2502(22.2%)5(55.6%)2(22.2%)
Unknown0(0.0%)2(66.7%)1(33.3%)

CEA (ng/ml)0.492
<516(19.3%)45(54.2%)22(26.5%)
≥51(14.3%)6(85.7%)0(0.0%)
Unknown3(30.0%)5(50.0%)2(20.0%)

Tumor location0.248
Upper 1/35(23.8%)9(42.9%)7(33.3%)
Middle 1/34(26.7%)10(66.7%)1(6.7%)
Lower 1/39(15.5%)33(56.9%)16(27.6%)
Total stomach2(28.6%)5(71.4%)0(0.0%)

Tumor size (cm)0.029
<57(12.3%)32(56.1%)18(31.6%)
≥513(29.5%)25(56.8%)6(13.6%)

Surgery type0.010
Subtotal gastrectomy8(12.1%)38(56.7%)20(30.3%)
Total gastrectomy12(34.3%)19(54.3%)4(11.4%)

Differentiation grade0.092
Moderate3(8.8%)20(58.8%)11(32.4%)
Poor17(25.4%)37(55.2%)13(19.4%)

Borrmann classification0.339
I0(0%)2(66.7%)1(33.3%)
II3(15.8%)9(47.4%)7(36.8%)
III14(21.2%)36(54.5%)16(24.2%)
IV3(23.1%)10(76.9%)0(0%)

pT0.006
10(0.0%)1(16.7%)5(83.3%)
20(0.0%)6(66.7%)3(33.3%)
34(11.8%)23(67.6%)7(20.6%)
416(30.8%)27(51.9%)9(17.3%)

pN0.023
00(0.0%)5(71.4%)2(28.6%)
10(0.0%)10(90.9%)1(9.1%)
24(15.4%)11(42.3%)11(42.3%)
316(28.1%)13(54.4%)10(17.5%)

pTNM0.009
Stage II0(0.0%)14(63.6%)8(36.4%)
Stage III20(25.3%)43(54.4%)16(20.3%)

LVI0.020
Negative2(5.4%)24(64.9%)11(29.8%)
Positive18(28.1%)33(51.6%)13(20.3%)

PNI0.673
Negative6(15.4%)23(59.0%)10(25.6%)
Positive14(22.6%)34(54.8%)14(22.6%)

Values in bold with  < 0.05. LVI, lymphatic and vascular invasion; PNI, perineural invasion.