Research Article

Immune Score Predicts Outcomes of Gastric Cancer Patients Treated with Adjuvant Chemoradiotherapy

Table 3

Univariate and multivariate Cox regression analysis for overall survival.

VariablesUnivariate analysisMultivariate analysis
HR (95% CI) valueHR (95% CI) value

Sex (F/M)0.819 (0.465, 1.442)0.489
Age (≥65/<65)1.723 (0.912, 3.256)0.0943.317 (1.430, 7.694)0.005
ECOG (1/0)1.169 (0.693, 1.972)0.559
LDH (≥250/<250 U/L)0.816 (0.293, 2.271)0.697
CEA (≥5/<5 ng/ml)2.881 (1.273, 6.523)0.0112.107 (0.798, 5.563)0.132
Tumor location0.189
 Upper 1/3reference
 Middle 1/31.748 (0.741, 4.121)0.202
 Lower 1/30.966 (0.487, 1.917)0.922
 Total stomach2.114 (0.733, 6.096)0.166
Surgery type (total/subtotal)2.287 (1.354, 3.864)0.0021.738 (0.871, 3.468)0.117
Size (≥5/<5 cm)1.103 (1.007, 1.207)0.0350.605 (0.325, 1.129)0.114
Grade (poor/moderate)2.187 (1.192, 4.010)0.0111.457 (0.646, 3.286)0.364
Borrmann classification0.1030.266
 I<0.0010.973<0.0010.977
 II0.301 (0.116,0.779)0.0130.284 (0.074, 1.092)0.067
 III0.586 (0.300,1.145)0.1180.537 (0.252, 1.144)0.107
 IVreferencereference
pTNM (III/II)4.685 (1.866, 11.762)0.0013.407 (1.135, 10.228)0.029
LVI (+/−)1.278 (0.738, 2.214)0.381
PNI (+/−)1.588 (0.916, 2.754)0.0990.955 (0.504, 1.965)0.988
IS<0.001<0.001
 Lowreferencereference
 Intermediate0.226 (0.122, 0.417)<0.0010.256 (0.119, 0.549)<0.001
 High0.068 (0.024, 0.189)<0.0010.087 (0.028, 0.273)<0.001

Values in bold with < 0.05. CI, confidence interval; HR, hazard ratio; F/M, female/male; LVI, lymphatic and vascular invasion; PNI, perineural invasion.