Research Article

Construction and Validation of an Autophagy-Related Prognostic Model for Osteosarcoma Patients

Table 2

Characteristics of genes used for constructing risk model.

GenesFull nameCategoryGene card IDFunction

ARL8BADP Ribosylation Factor Like GTPase 8BProtein CodingGC03P005122Plays a role in lysosome motility
USP10Ubiquitin Specific Peptidase 10Protein CodingGC16P084734A key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes
AMBRA1Autophagy and Beclin 1 Regulator 1Protein CodingGC11M061101Regulates autophagy and development of the nervous system
LGALS8Galectin 8Protein CodingGC01P236518A sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy
AKT1S1AKT1 Substrate 1Protein CodingGC19M049869Regulates cell growth and survival in response to nutrient and hormonal signals
BNIP3BCL2 Interacting Protein 3Protein CodingGC10M131966Participates in mitochondrial protein catabolic process leading to the degradation of damaged proteins inside mitochondria
VPS18Vacuolar Protein Sorting Protein 18Protein CodingGC15P040894Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways.
SAFB2Scaffold Attachment Factor B2Protein CodingGC19M005587Functions as an estrogen receptor corepressor and can also inhibit cell proliferation
PTPRSProtein Tyrosine Phosphatase Receptor Type SProtein CodingGC19M005157Required for normal brain development
CDK5Cyclin Dependent Kinase 5Protein CodingGC07M151053Essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death
MAPKAP1MAPK Associated Protein 1Protein CodingGC09M125437Regulates cell growth and survival
TBC1D14TBC1 Domain Family Member 14Protein CodingGC04P006910Plays a role in the regulation of starvation-induced autophagosome formation