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| Author | Sample size (n) | Methods | Results |
|
| Battaglini et al. [41] | 51 randomized controlled trials | Meta-analysis of studies including aerobic exercise, resistance programs, and combination of both. | Improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life. |
| Bland et al. [42] | n = 68 | Women with early stage breast cancer receiving chemotherapy participated in supervised aerobic and resistance exercise was prescribed three times per week during treatment, then one to two times per week for 20 additional weeks. | Higher baseline quality of life (QoL) predicted higher attendance during chemotherapy and higher QoL, measured at the end of treatment, and predicted higher attendance posttreatment. |
| De Jesus et al. [39] | n = 24 | Feasibility study looking at a 16 week CR prescription program for breast cancer patients who rated their fatigue >4/10 after completion of adjuvant chemotherapy. | Adherence rate to exercise program was 30.3% to the cardiac rehab program. Improvements were seen in fatigue. No significant changes in body composition, aerobic exercise capacity, and activity patterns. |
| Dieli-Conwright et al. [43] | n = 100 | Randomized controlled trial with 16-week combined aerobic and resistance exercise training in ethnically diverse sedentary, overweight and obese survivors of breast cancer | Sarcopenic obesity, circulating biomarkers (insulin, leptin, and adiponectin) significantly improved postintervention at 3-month follow-up |
| Dieli-Conwright et al. [44] | n = 200 | Breast cancer survivors with sedentary lifestyles who are obese or overweight participated in a 16-week aerobic and resistance exercise training. | At postintervention, the exercise group was superior to usual care for quality of life, fatigue, depression, estimated VO2 max , muscular strength, osteocalcin, and bone specific alkaline phosphatase. |
| Dolan et al. [45] | n = 152 | Retrospectively analyzed eligible charts of patients that participated in weekly supervised personalized aerobic and resistance exercise session for 22 group sessions plus 12 group educational sessions | Cardiorespiratory fitness (VO2 peak) improved by 14% with significant improvements in quality of life and depression scores. |
| Howden et al. [46] | n = 28 | Patients with early stage breast cancer undergoing anthracycline therapy chose exercise training or usual care. The exercise training group completed 2 × 60 minute supervised exercise sessions per week. | Exercise training attenuated the VO2 decrease during chemotherapy. Functional disability can be prevented with exercise training. |
| Hsieh et al. [40] | n = 96 | Patients in individually supervised oncology rehabilitation setting based on CR. 2-3 times/wk both aerobic and resistance and stretching. | ↑ VO2 max and time on treadmill for all groups. |
| Juvet et al. [47] | n = 3418
25 randomized controlled trials | Systemic review of trials with physical exercise intervention versus a control group. | An increase in physical functioning and a decrease in fatigue were observed after a physical exercise intervention. |
| Kirkham et al. [48] | n = 73 | Patients received adjuvant chemotherapy participated to varying degrees in supervised aerobic and resistance exercise during chemotherapy +/- radiation and for 20 weeks. | Chemotherapy resulted in increased HRrest and tachycardia, decreased blood pressure. Anthracyclines, trastuzumab, and left‐sided radiation were associated with HRrest elevations and impairments of HRrecovery, but exercise training at least twice a week mitigated these changes. |
| Knobf et al. [49] | n = 154 | Randomized controlled trial. Compared 2-month aerobic-resistance fitness center intervention to home-based physical activity. | Fitness center intervention had significantly improved time on treadmill, improved heart rate recovery at 1 min, greater MET minutes/week, a trend for improved insulin resistance, and stable insulin levels compared to the home-based physical activity group. |
| Lee et al. [50] | n = 4980 | Analysis and multivariable linear regressions were used to examine the association between resting heart rate and metabolic risk factors, including systolic blood pressure, diastolic blood pressure, glucose, triglyceride, total cholesterol, high-density lipid cholesterol, and low-density lipid cholesterol in breast cancer survivors. | Strong positive association of resting heart rate with fasting glucose, triglycerides, and diastolic blood pressure in breast cancer survivors |
| Mutrie et al. [51] | n = 203 | Patients in a 12-week supervised group exercise program during treatment for early stage breast cancer, with six-month follow-up. | Functional and psychological benefit after 12 weeks and six months later.
No improvement in general scale of QoL (FACT-G).
Improvement in mood and cancer specific QoL scale (FACT-B). |
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