Comprehensive Analysis of Differentially Expressed Long Noncoding RNA-mRNA in the Adenoma-Carcinoma Sequence of DNA Mismatch Repair Proficient Colon Cancer

Figure 2

STC analysis of the dysregulated DEGs in multistage colonic mucosa tissues. (a) Twenty-six clusters for the expression pattern of DEGs, 15 lncRNA expression patterns, and nine mRNA expression patterns showed significant values (colored boxes, /26). Each box represents a model expression profile, the lower number in the profile box is the value, and the upper number is the model profile number. (b) Cluster 25 (173 lncRNAs) gradually increased, cluster 0 (87 lncRNAs) showed a decreasing trend, cluster 23 contained 207 lncRNAs that gradually increased from NC to adenoma and then decreased in CC, and cluster 25 (146 mRNAs) gradually increased. Horizontal axis represents different stages of colonic mucosal protruding lesions and the vertical axis shows the time series for the lncRNA/mRNA expression levels. r normalized with log transformation.

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