Research Article

A 10-Gene Signature Identified by Machine Learning for Predicting the Response to Transarterial Chemoembolization in Patients with Hepatocellular Carcinoma

Table 2

Top 20 genes and their corresponding coefficients in SVM model.

GeneOccurrenceRanking sumAverage rankCoefficient

SLC9A3-AS110/10313.1
TSPAN810/10313.10.053
SLAIN110/10686.8
SPARCL110/10707−0.098
PKIB10/1012112.1
S100A810/1012812.80.064
AQP110/1021221.2−0.069
ERAP29/109810.9
TYRO39/10135150.084
TIAM19/1017119−0.054
HERC69/1022424.9−0.054
ZC3HAV1L9/1024827.6
LOX9/10306340.065
FABP48/1017822.2−0.033
PEG108/1019424.20.027
SLC35G18/1025632
VWF7/10689.7
CXCL117/108912.7
DHRS27/109313.3
ADH1C7/1010314.7

SLC9A3-AS1: SLC9A3 antisense RNA 1; TSPAN8: Tetraspanin 8; SLAIN1: SLAIN motif family member 1; SPARCL1: SPARC-like 1; PKIB: cAMP-dependent protein kinase inhibitor beta; S100A8: S100 calcium binding protein A8; AQP1: aquaporin 1; ERAP2: endoplasmic reticulum aminopeptidase 2; TYRO3: TYRO3 protein tyrosine kinase; TIAM1: TIAM Rac1 associated GEF 1; HERC6: HECT and RLD domain-containing E3 ubiquitin protein ligase family member 6; ZC3HAV1L: zinc finger CCCH-type containing, antiviral 1 like; LOX: lysyl oxidase; FABP4: fatty acid binding protein 4; PEG10: paternally expressed 10; SLC35G1: solute carrier family 35 member G1; VWF: von Willebrand factor; CXCL11: C-X-C motif chemokine ligand 11; DHRS2: dehydrogenase/reductase 2; ADH1C: alcohol dehydrogenase 1C.