Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer

Table 1

Modified residues of histones, different histone modifications, and their impact on transcriptional regulation.

Modified residues of histones	Histone modification	Transcription regulation
Lysine	Acetylation	Activation
Lysine me1, me2, and me3	Methylation (lysine)	Repression/activation
Arginine me1, arginine me2a, and arginine me2s	Methylation (arginine)	Repression/activation
Serine, threonine, and tyrosine	Phosphorylation	Activation
Lysine	Ubiquitination	Activation
Glutamic	ADP-ribosylation	Repression
Lysine	Sumoylation	Repression