Epi-miRNAs: Regulators of the Histone Modification Machinery in Human Cancer

Table 8

miRNA-mediated regulation of histone kinases.

Kinase groups	Target gene	miRNAs	Cancer tissue or cancer cell line	Reference
AGC	RPS6KA4 (MSK2)	miR-517a	Bladder cancer cell lines	[159]
	PRKCD	miR-181a	Cervical squamous cells	[160, 161]
	PRKCD	miR-181c	Ovarian cancer tissues	[162]
	PRKCD	miR-224	Ovarian papillary serous carcinoma	[163]
	PRKCB	miR-197-3p	Gastric cancer	[164]
	RSK2	miR-634	Ovarian cancer	[165]
	PRKDC	miR-488-3p	Malignant melanoma	[166]
Nonreceptor tyrosine kinase families	JAK2	mR-543	Hepatocellular carcinoma	[167]
	JAK2	miR-216a	Pancreatic cancer	[168, 169]
	JAK2	miR-204	Breast cancer	[170]
	JAK2	miR-204	Non-small lung cancer cell lines	[171]
	JAK2	miR-375	Gastric cancer	[172, 173]
	JAK2	miR-135a	Hodgkin lymphoma	[174]
	JAK2	miR-135a	Renal cancer	[175]
	JAK2	miR-135a	Gastric carcinoma	[176]
CMGC	CDK3	miR-873	Breast cancer	[177]
	CDK3	miR-4469	Primary breast tumors	[178]
	MAP3K8	miR-589-5p	Hepatocellular carcinoma	[179]
	MAP3K8	miR-144-3p	Renal cell carcinoma	[180]
	MAP3K8	miR-509-3p	Renal cell carcinoma	[181]
	GSK3B	miR-769	Melanoma	[182]
Tyrosine kinase-like (TKL)	LIMK2	miR-135a	Bladder cancer	[183]
Other kinases family	NEK6	miR-23	Hepatocellular carcinoma	[184]
	NEK6	miR-26	Marek’s disease lymphoma	[185]
	NEK6	miR-506-3p	Retinoblastoma	[186]
	AURKA	miR-124-3p	Bladder cancer	[187]
	AURKA	miR-124-3p	Glioblastoma	[188]
	AURKA	miR-32	Non-small-cell lung cancer	[189]
	AURKA	miR-137	Multiple myeloma	[190]
	AURKA	let-7	Hepatocellular cancer	[191]
	AURKA	miR-490	Hepatocellular carcinoma	[192]
	AURKA	miR-4715-3p	Gastrointestinal cancers	[193]
	BUB1	miR-490-5p	Hepatocellular carcinoma	[194]
	BUB1	miR-145-3p	Prostate cancer	[195]
CAMK	CHEK2 (Chk2)	miR-191	Osteosarcoma	[196]
	CHEK2 (Chk2)	miR-182-5p	Breast cancer	[197]
	CHEK1 (Chk1)	miR-195	Non-small-cell lung cancer	[198]
	CHEK1 (Chk1)	miR-195	Colon cancer	[199]
	CHEK1 (Chk1)	miR-497	Hepatocellular carcinoma	[200]
	CHEK1 (Chk1)	miR-145	Bladder cancer	[201]
	CHEK1 (Chk1)	miR-424	Cervical cancer	[202]
	CHEK1 (Chk1)	miR-15	Breast cancer cells	[203]
	CHEK1 (Chk1)	miR-26a	Prostate cancer	[204]
	DAPK3	miR-1307	Ovarian cancer cell lines	[205]
	AMPK	miR-451	Colorectal cancer	[206]
	AMPK	miR-25-5p	Colorectal cancer	[207]
	AMPK	miR-101	Breast cancer	[208]
	AMPK	miR-34	Prostate cancer	[209]
STE	STK4	miR-18a	Prostate cancer	[210]
	PAK2	miR-4779	Colon cancer	[211]
	PAK2	miR-216a-5p	Breast cancer	[212]
	PAK2	miR-137	Melanoma	[213]
	PAK2	miR-75p	Non-small-cell lung cancer	[214]
	PAK2	miR-134	Human ovarian cancer cells	[215]
	PAK2	miR-922	Oral squamous cell carcinoma	[216]
	PAK2	miR-26a	Hepatocellular carcinoma	[217]