Research Article
Association between Cervical Lymph Node Metastasis and the Incidence of Radiation-Induced Hypothyroidism in Nasopharyngeal Carcinoma
Table 1
The general clinical characteristics of 206 patients with nasopharyngeal carcinoma.
| | Variables | Euthyroidism | Hypothyroidism | |
| | Sex (%) | | | 0.004 | | Male | 73 (76.8) | 63 (56.8) | | | Female | 22 (23.2) | 48 (43.2) | | | Age (mean [SD]) | 52.81 (10.61) | 50.14 (10.68) | 0.075 | | Pretreatment TSH concentration | 1.29 (0.92, 1.74) | 2.29 (1.58, 3.06) | <0.001 | | Volume (cm3) | 16.16 (13.43, 19.98) | 12.82 (10.79, 16.13) | <0.001 | | T-stage (%) | | | 1 | | T1–2 | 18 (18.9) | 21 (18.9) | | | T3–4 | 77 (81.1) | 90 (81.1) | | | N-stage (%) | | | 0.067 | | N0–1 | 39 (41.1) | 31 (27.9) | | | N2–3 | 56 (58.9) | 80 (72.1) | | | M-stage (%) | | | 0.656 | | M0 | 92 (96.8) | 105 (94.6) | | | M1 | 3 (3.2) | 6 (5.4) | | | Clinical stage (%) | | | 0.981 | | I–II | 7 (7.4) | 7 (6.3) | | | III–IV | 88 (92.6) | 104 (93.7) | | | Neoadjuvant chemotherapy (%) | | | | | No | 7 (7.4) | 5 (4.5) | 0.564 | | Yes | 88 (92.6) | 106 (95.5) | | | Distance from thyroid (%) | | | 0.005 | | 0–1 cm | 13 (13.7) | 29 (26.1) | | | 1–2 cm | 16 (16.8) | 30 (27.0) | | | 2–3 cm | 31 (32.6) | 31 (27.9) | | | >3 cm | 35 (36.8) | 21 (18.9) | | | Number. Level Ib (%) | | | 0.538 | | 0 | 87 (91.6) | 100 (90.1) | | | 1-2 | 7 (7.4) | 11 (9.9) | | | ≥3 | 1 (1.1) | 0 (0.0) | | | Number. Level IIa (%) | | | 0.046 | | 0 | 12 (12.6) | 5 (4.5) | | | 1–2 | 69 (72.6) | 95 (85.6) | | | ≥3 | 14 (14.7) | 11 (9.9) | | | Number. Level IIb (%) | | | 0.001 | | 0 | 16 (16.8) | 4 (3.6) | | | 1–2 | 48 (50.5) | 78 (70.3) | | | ≥3 | 31 (32.6) | 29 (26.1) | | | Number. Level III (%) | | | 0.048 | | 0 | 36 (37.9) | 27 (24.3) | | | 1–2 | 42 (44.2) | 51 (45.9) | | | ≥3 | 17 (17.9) | 33 (29.7) | | | Number. Level IVa (%) | | | 0.006 | | 0 | 70 (73.7) | 58 (52.3) | | | 1–2 | 21 (22.1) | 41 (36.9) | | | ≥3 | 4 (4.2) | 12 (10.8) | | | Number. Level IVb (%) | | | 0.173 | | 0 | 95 (100.0) | 107 (96.4) | | | 1–2 | 0 (0.0) | 4 (3.6) | | | Number. Level Va (%) | | | 0.04 | | 0 | 64 (67.4) | 58 (52.3) | | | 1–2 | 30 (31.6) | 47 (42.3) | | | ≥3 | 1 (1.1) | 6 (5.4) | | | Number. Level Vb (%) | | | 0.163 | | 0 | 81 (85.3) | 85 (76.6) | | | 1–2 | 14 (14.7) | 26 (23.4) | | | Number. Level Vc (%) | | | 1 | | 0 | 93 (97.9) | 108 (97.3) | | | 1–2 | 2 (2.1) | 3 (2.7) | | | Number. Level VIIa (%) | | | 0.898 | | 0 | 24 (25.3) | 30 (27.0) | | | 1–2 | 71 (74.7) | 81 (73.0) | | | Maxdiameter. Level Ib (%) | | | 0.48 | | 0 cm | 87 (91.6) | 100 (90.1) | | | 0–1 cm | 7 (7.4) | 7 (6.3) | | | ≥1 cm | 1 (1.1) | 4 (3.6) | | | Maxdiameter. Level IIa (%) | | | 0.073 | | 0 cm | 12 (12.6) | 5 (4.5) | | | 0–1 cm | 56 (58.9) | 65 (58.6) | | | ≥1 cm | 27 (28.4) | 41 (36.9) | | | Maxdiameter. Level IIb (%) | | | 0.006 | | 0 cm | 16 (16.8) | 4 (3.6) | | | 0–1 cm | 41 (43.2) | 57 (51.4) | | | ≥1 cm | 38 (40.0) | 50 (45.0) | | | Maxdiameter. Level III (%) | | | 0.07 | | 0 cm | 36 (37.9) | 27 (24.3) | | | 0–1 cm | 47 (49.5) | 72 (64.9) | | | ≥1 cm | 12 (12.6) | 12 (10.8) | | | Maxdiameter. Level IVa (%) | | | 0.007 | | 0 cm | 70 (73.7) | 58 (52.3) | | | 0–1 cm | 22 (23.2) | 46 (41.4) | | | ≥1 cm | 3 (3.2) | 7 (6.3) | | | Maxdiameter. Level IVb (%) | | | 0.251 | | 0 cm | 95 (100.0) | 107 (96.4) | | | 0–1 cm | 0 (0.0) | 2 (1.8) | | | ≥1 cm | 0 (0.0) | 2 (1.8) | | | Maxdiameter. Level Va (%) | | | 0.079 | | 0 cm | 64 (67.4) | 58 (52.3) | | | 0–1 cm | 25 (26.3) | 45 (40.5) | | | ≥1 cm | 6 (6.3) | 8 (7.2) | | | Maxdiameter. Level Vb (%) | | | 0.238 | | 0 cm | 81 (85.3) | 85 (76.6) | | | 0–1 cm | 12 (12.6) | 20 (18.0) | | | ≥1 cm | 2 (2.1) | 6 (5.4) | | | Maxdiameter. Level Vc (%) | | | 1 | | 0 cm | 93 (97.9) | 108 (97.3) | | | 0–1 cm | 2 (2.1) | 2 (1.8) | | | ≥1 cm | 0 (0.0) | 1 (0.9) | | | Maxdiameter. Level VIIa (%) | | | | | 0 cm | 24 (25.3) | 30 (27.0) | 0.653 | | 0–1 cm | 48 (50.5) | 60 (54.1) | | | ≥1 cm | 23 (24.2) | 21 (18.9) | | | Number. all | 7.00 (5.00, 10.00) | 9.00 (6.00, 11.00) | 0.008 | | Maxdiameter. all | 1.04 (0.81, 1.38) | 1.15 (0.94, 1.54) | 0.039 |
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The values in the table are N (%) or median (Q25–Q75) unless otherwise indicated; Maxdiameter: maximum diameter; , , . |
