Research Progress and Prospects of Autophagy in the Mechanism of Multidrug Resistance in Tumors

Figure 3

A schematic diagram of the PI3KC3 complex involved in the regulation of autophagy. The PI3KC3 complex is necessary for autophagy and is composed of BECN1, ATG14, Vps15, and Vps34. The complex can be positively regulated by AMBRA1 and negatively regulated by Bcl-2, which binds to BECN1 and blocks the combination with the complex. The UVRAG protein is a BECN1 positive mediator, and it can also mediate the activation of the PICKC3 complex to promote autophagy.