Components of NOTCH Signaling for Uterine Cancer Patients’ Prognosis
Table 2
Results of Cox multivariate models (adjustments of each gene expression to age and clinical-pathological characteristics) for overall survival of patients with uterine cancer.
Gene
value
Hazard ratio
95.0% CI for hazard ratio
Fold change of NOTCH2 expression
mRNA decrease over 4 folds (reference group)
—
1
—
mRNA increase or decrease up to 4 folds
0.003
3.4
1.5–7.9
Fold change of NOTCH3 expression
mRNA decrease over 2 folds (reference group)
—
1
—
mRNA increase or decrease up to 2 folds
0.044
2.3
1.0–5.1
Fold change of NOTCH4 expression
mRNA decrease more than 1 fold (reference group)
—
1
—
mRNA increase more than 1 fold
0.013
3.0
1.3–7.3
Fold change of JAG2 expression
mRNA increase less than 2 folds and decrease (reference group)
—
1
—
mRNA increase more than 2 folds
0.009
3.4
1.4–8.5
Fold change of HES1 expression
mRNA increase less than 2 folds and decrease (reference group)
