Clinical Treatment Study of Secondary Multiple Squamous Cell Carcinoma with Psoriasis Vulgaris

Table 1

Gene variants that affect dermatology response to therapy results for 5-FU and dapsone.

Gene	Polymorphism	Drug	Population	Level of evidence	Application in clinic	Category
HLA-B	13 : 01 : 01	Dapsone	Africans	1B	No	Toxicity
G6PD	rs1050829 A−	Dapsone	Asian	2A	No	Toxicity
	rs1050830 A+	Dapsone	Africans	—	No	Toxicity
DYPD	rs67376798	5-FU	Several groups	1A	Yes	Toxicity
	rs3918290	5-FU		1A	Yes	Toxicity
	rs55886062	5-FU		1A	Yes	Toxicity