Cigarette smoking accounts for at least 30% of all cancer deaths. It is linked with an increased risk of cancers including lung, larynx, oral cavity, pharynx, esophagus, stomach, pancreas, cervix, kidney, bladder, and acute myeloid leukemia. Despite the gravity of a cancer diagnosis in smoking, it accounts for less than half of the deaths related to smoking each year. Smoking is also one of the major causes of heart disease, aneurysms, bronchitis, emphysema, and stroke. Some studies have also linked smoking to macular degeneration, an eye disease that may lead to blindness. Over 4000 compounds have been identified in cigarette smoke, 60 of which have been found to be complete carcinogens, tumor initiators, promoters, and/or cocarcinogens in various in vitro and animal bioassays. Second-hand smoke, also known as passive smoke or environmental tobacco smoke, has been also associated with bladder cancer and is the cause of about 38000 deaths annually in America alone. Reports by the International Agency for Research on Cancer (IACR) have classified second-hand tobacco smoke (passive smoking) as an established human carcinogen.

We invite investigators to contribute original research articles as well as review articles that will enhance the knowledge and risk of cigarette smoke linked with human cancer and the understanding of the molecular pathology underlying the disorders that result from active and passive smoke. Potential topics include but are not limited to:

• Second-hand smoke–cancer and chemotherapy
• Nicotine addiction and its effect
• Cigarette smoke and cancer biomarkers
• Tobacco and oral cancer
• Leukoplakia, submucous fibrosis, and precancerous lesions of tobacco-induced cancer
• Genetic or epigenetic alterations in active and passive smoke
• Epidemiology of tobacco-induced cancer
• Role of third-hand smoking in tumor initiation/promotion
• Dietary supplements and cigarette smoke
• Molecular pathology, cellular signaling, and response to active and passive smoking
• CYP450 and tobacco-related cancers
• Race and sex differences in cancer risk associated with cigarette smoking
• Cigarette smoking and pre/postoperative complications

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