Journal of Oncology

Molecular Genetic Markers in Female Reproductive Cancers


Publishing date
01 Dec 2009
Status
Published
Submission deadline
01 Jun 2009

Lead Editor

1Departments of Gynecology and Obstetrics and Oncology, and Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA

2Department of Pathology, Norwegian Radium Hospital, Rikshospitalet University Hospital, Montebello, 0310 Oslo, Norway

3Departments of Pathology and Microbiology and Immunology, The University of South Carolina School of Medicine, Columbia, SC 29203, USA

4Department of Medicine, National Taiwan University, Taipei 10617, Taiwan

5Center for Hematology and Oncology, Department of Internal Medicine I, Wilhelminenspital, 1160 Vienna, Austria


Molecular Genetic Markers in Female Reproductive Cancers

Description

Cancer is a complex genetic disease as a result of accumulated genomic alterations which serve as the driving force in initiating tumor development and propelling tumor progression. The Darwinian evolution theory of cancer predicts that clinically detectable tumors harbor the molecular genetic changes that are causally related to uncontrolled growth, survival in dynamic microenvironment, invasion into surrounding normal tissues, and metastasis to distant organs. Various forms of genomic abnormalities have occurred in cancers, such as point mutations, DNA copy number alterations, and chromosomal rearrangements. Proto-oncogenes are typically activated by gene amplifications, gene translocations, and activating intragenic mutations, whereas tumor suppressors are inactivated by gene deletions (loss of heterozygosity or homologous deletion), inactivating intragenic mutations, and epigenetic silencing. Recent advances in molecular genomic technology and the success of human genome project have empowered investigators with new tools in analyzing cancer genome in great details and have expedited the discovery of new cancer-associated genes. Decoding the genetic history present in tumor DNA, as well as identification and characterization of molecular changes involving cancer-associated genes and the pathways they controlled, has not only shed new light on the molecular etiology of cancer, but also has promised for the development of new diagnostic markers and novel therapeutics.

In this special issue, we invite authors to present original research articles as well as timely reviews that will stimulate the continuing efforts in identifying and characterizing new biomarkers and therapeutic targets in female reproductive cancers including breast, ovarian, endometrial, and cervical cancer. Studies that evaluate mutations, bioinformatics for genome-wide data analysis, biomarkers to predict prognosis and treatment outcome, as well as preclinical and clinical studies in new therapeutic development are particularly welcome. Translational studies that focus on assessing the clinical significance of expression of biomarkers are also encouraged.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jo/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 307460
  • - Editorial

Molecular Genetic Markers in Female Reproductive Cancers

Tian-Li Wang | Ben Davidson | ... | Gudrun Pohl
  • Special Issue
  • - Volume 2010
  • - Article ID 285191
  • - Research Article

Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas

Stefanie M. Ueda | Kai Lee Yap | ... | Ie-Ming Shih
  • Special Issue
  • - Volume 2010
  • - Article ID 126295
  • - Review Article

Precursor Lesions of High-Grade Serous Ovarian Carcinoma: Morphological and Molecular Characteristics

Amy L. Gross | Robert J. Kurman | ... | Kala Visvanathan
  • Special Issue
  • - Volume 2010
  • - Article ID 364508
  • - Research Article

Lack of a Y-Chromosomal Complement in the Majority of Gestational Trophoblastic Neoplasms

Kai Lee Yap | Michael J. Hafez | ... | Ie-Ming Shih
  • Special Issue
  • - Volume 2010
  • - Article ID 297671
  • - Research Article

Germline Mutations and Polymorphisms in the Origins of Cancers in Women

Kim M. Hirshfield | Timothy R. Rebbeck | Arnold J. Levine
  • Special Issue
  • - Volume 2010
  • - Article ID 821717
  • - Research Article

Loss of miR-200c: A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers

Dawn R. Cochrane | Erin N. Howe | ... | Jennifer K. Richer
  • Special Issue
  • - Volume 2010
  • - Article ID 426956
  • - Review Article

Role of Chemokine Network in the Development and Progression of Ovarian Cancer: A Potential Novel Pharmacological Target

Federica Barbieri | Adriana Bajetto | Tullio Florio
  • Special Issue
  • - Volume 2010
  • - Article ID 139087
  • - Research Article

The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Tae Hoon Kim | Jinrong Wang | ... | Francesco J. DeMayo
  • Special Issue
  • - Volume 2010
  • - Article ID 646340
  • - Research Article

Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal Evolution

Francesca Micci | Lisbeth Haugom | ... | Sverre Heim
  • Special Issue
  • - Volume 2010
  • - Article ID 932371
  • - Review Article

Ovarian Cancer Pathogenesis: A Model in Evolution

Alison M. Karst | Ronny Drapkin
Journal of Oncology
 Journal metrics
Acceptance rate33%
Submission to final decision94 days
Acceptance to publication49 days
CiteScore3.220
Impact Factor2.600
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