Journal of Oncology

Promising Drug Targets for Cancer Therapeutics


Publishing date
01 Jun 2022
Status
Closed
Submission deadline
14 Jan 2022

1B.S. Abdur Rahman Crescent Institute of Science and Technology, Chennai, India

2Universiti Putra Malaysia, Serdang, Malaysia

3Periyar University, Dharmapuri, India

This issue is now closed for submissions.
More articles will be published in the near future.

Promising Drug Targets for Cancer Therapeutics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

The genesis and progression of cancer are exceptionally complex. The incidence rate of diverse cancer types is increasing alarmingly around the world. The major problems in the development of cancer drugs are chemo-resistance and tumor recurrence. Conventional therapies have proved unsuccessful in eliminating tumors completely.

Abnormal singaling has been implicated in tumor formation, including the phosphoinositide 3-kinase (PI3K)/Akt, mammalian target of rapamycin (mTOR), Wnt/β-Catenin, mitogen-activated protein kinase (MAPK), signal transducer and activator of transcription 3 (STAT3), and notch signaling pathways. Targeted chemotherapy has been shown to be successful in treating certain malignancies. However, its efficacy has often been limited by drug resistance and side effects on normal tissues and cells. Immunotherapy is one promising area that has attracted much interest. Along with abnormal tumor signaling pathways, targeting cancer stem cells and microRNAs are playing key roles in cancer drug development. It is well known that cancer stem cells are the major reason for the drug resistance and tumor recurrence. MicroRNAs regulate multiple key signaling pathways that promote tumorigenesis.

This Special Issue aims to collate original research and review articles that describe some of these promising anticancer targets, including (PI3K)/Akt, mTOR, Wnt/β-Catenin, MAPK, STAT3, and notch signaling pathways along with cancer stem cells, microRNAs, and other key targets. In addition, articles describing promising drug candidates of natural and synthetic origin under various phases of clinical trials are also welcome.

Potential topics include but are not limited to the following:

  • Notch signaling and its regulation in cancer
  • The role of oncomirs in the regulation of various cancers
  • Cancer stem cells and their role in chemo-resistance
  • Immunotoxins and immunotherapy
  • Promising natural agents targeting microRNAs in cancer
  • Exosome-based therapy to target cancer stem cells
  • Potential drugs targeting the Hedgehog pathway for the treatment of cancer
  • Antibody-cytokine fusion proteins: a novel class of biopharmaceuticals for the therapy of cancer
  • The centrosome: a future candidate in cancer therapy
  • Sphingosine kinase as a target to treat gastrointestinal cancers
  • mTOR pathway inhibitors as anticancer agents
  • CXCR4 and CCR7 targets in cancer therapy
  • STAT3 inhibitors for the treatment of inflammation-driven cancers
  • Plant-derived natural products and synthetic compounds acting on key signaling pathways in cancer

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 9877354
  • - Research Article

Analysis of the Correlation between Nutritional Status and Quality of Life of Patients with Gynaecological Ovarian Cancer during Postoperative Chemotherapy

Xiaoming Shi | Yuchun Lv | ... | Shengjun You
  • Special Issue
  • - Volume 2022
  • - Article ID 5989419
  • - Research Article

The Landscape of Using Glycosyltransferase Gene Signatures for Overall Survival Prediction in Hepatocellular Carcinoma

Qiang Cai | Shizhe Yu | ... | Zhiyong Yu
  • Special Issue
  • - Volume 2022
  • - Article ID 4711935
  • - Research Article

Effect of Refined Perioperative Nursing on the Efficacy of Noninvasive Ventilation in Elderly Patients with Lung Cancer and Respiratory Failure

Li Huang | Chun Feng
  • Special Issue
  • - Volume 2022
  • - Article ID 7777446
  • - Research Article

The Impact of Palliative Care and Nursing Intervention on the Psychology and Quality of Life of Elderly Patients with Colorectal Cancer

Ai Zhang | He Fu
  • Special Issue
  • - Volume 2022
  • - Article ID 9690401
  • - Research Article

Multifactorial Analysis of Clinical Prognosis of Liver Metastasis and Vascular Intervention Combined with Ablation in Colorectal Cancer

WenJi Lin | CongHui Zhu | ... | Yan Liu
  • Special Issue
  • - Volume 2022
  • - Article ID 9038230
  • - Research Article

Effect of CDCA5 on Proliferation and Metastasis of Triple Negative Breast Cancer Cells under shRNA Interference Technology

Yilin Li | Wei Peng | ... | Ting Li
  • Special Issue
  • - Volume 2022
  • - Article ID 8030262
  • - Research Article

Analysis of the Application Value of Ultrasound Imaging Diagnosis in the Clinical Staging of Thyroid Cancer

Fengying Zhang | Yunxuan Sun | ... | Zhaolan Sun
  • Special Issue
  • - Volume 2022
  • - Article ID 4327977
  • - Research Article

Research on the Guiding Effect of CTCs on Postoperative Adjuvant Therapy for Patients with Early Stage Endometrial Cancer

Liguo Li | Huihui Zhai | ... | Hongfen He
  • Special Issue
  • - Volume 2022
  • - Article ID 7427146
  • - Research Article

Clinical Analysis of C-Shaped Embedded Pancreaticojejunostomy in Pancreaticoduodenectomy

Hui Huang | Jichun Sun | ... | Xiao Yu
  • Special Issue
  • - Volume 2022
  • - Article ID 1907322
  • - Research Article

Clinical Analysis of 137 Cases of Ovarian Tumors in Pregnancy

Qi Yin | Min Zhong | ... | XiuJie Sheng
Journal of Oncology
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