Journal of Oncology

Cancer Cell Plasticity


Publishing date
01 Oct 2019
Status
Closed
Submission deadline
31 May 2019

1University of Salento, Lecce, Italy

2“G.d’Annunzio” University of Chieti-Pescara, Pescara, Italy

This issue is now closed for submissions.
More articles will be published in the near future.

Cancer Cell Plasticity

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Human cells are very plastic. This is made evident during embryogenesis and after injury, when this inherent plasticity allows cells to generate novel tissues or to regenerate, but it is also present in mature cells that can be reprogrammed into other cell types. The mechanisms underlying this transformation are finely regulated and coordinated in a spatiotemporal-specific manner by a large variety of stimuli. Under pathological conditions including tumor formation and progression, these layers of regulation are lost generating multiple cell populations and conferring tumor cells with novel functional properties. For example, a growing number of studies have demonstrated that the activation of the epithelial to mesenchymal transition (EMT) process can generate cells with enhanced motility, increased invasive potential, and stemness properties. The molecular determinants at the basis of this plasticity, the functional relationships between these different populations, and the potential clinical implications remain to be fully explored. Overall, this represents a challenge to the accurate diagnosis and treatment of tumors.

This special issue aims to highlight the plasticity of cells at different stages of tumor progression and the major contributing factors at the basis of this heterogeneity including the role of the surrounding microenvironment. Central to this special issue will be also the role of EMT and its reversal process, mesenchymal to epithelial transition (MET), in conferring cell plasticity and the molecular basis underlying these processes at the physiological or pathological level. Moreover, considering the dynamic and complex nature of this biological field, important insights gained through the application and the integration of omics and novel experimental methods and analytical approaches in vitro and in vivo will be also considered.

We invite the authors to contribute original research articles as well as review articles that will address recent development in the above areas.

Potential topics include but are not limited to the following:

  • Cellular networks regulating cancer cell plasticity
  • Cell plasticity and epithelial to mesenchymal transition
  • Plasticity and cancer stem cells
  • Genomics and proteomics for analysis of plasticity in tumors
  • Biological and clinical implications of cell plasticity
  • Novel technological and experimental approaches for investigating cancer cell plasticity

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 1396429
  • - Erratum

Erratum to “Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?”

Gabor Tax | Andrea Lia | ... | Pietro Roversi
  • Special Issue
  • - Volume 2020
  • - Article ID 8947367
  • - Corrigendum

Corrigendum to “Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation”

D. Brocco | P. Lanuti | ... | N. Tinari
  • Special Issue
  • - Volume 2020
  • - Article ID 6153432
  • - Erratum

Erratum to “Frizzled-10 Extracellular Vesicles Plasma Concentration Is Associated with Tumoral Progression in Patients with Colorectal and Gastric Cancer”

Maria Principia Scavo | Antonio Cigliano | ... | Gianluigi Giannelli
  • Special Issue
  • - Volume 2020
  • - Article ID 3961735
  • - Review Article

Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment

Fausta Ciccocioppo | Paola Lanuti | ... | Sebastiano Miscia
  • Special Issue
  • - Volume 2019
  • - Article ID 5649846
  • - Research Article

Expression Analysis of the Mediators of Epithelial to Mesenchymal Transition and Early Risk Assessment of Therapeutic Failure in Laryngeal Carcinoma

Nora Kariche | Nabila Moulaï | ... | Mehdi Bourouba
  • Special Issue
  • - Volume 2019
  • - Article ID 4216750
  • - Review Article

The CTLH Complex in Cancer Cell Plasticity

Nickelas Huffman | Dario Palmieri | Vincenzo Coppola
  • Special Issue
  • - Volume 2019
  • - Article ID 5879616
  • - Research Article

Circulating Cancer Stem Cell-Derived Extracellular Vesicles as a Novel Biomarker for Clinical Outcome Evaluation

D. Brocco | P. Lanuti | ... | N. Tinari
  • Special Issue
  • - Volume 2019
  • - Article ID 2403483
  • - Review Article

Mathematical Models of Cancer Cell Plasticity

Hasitha N. Weerasinghe | Pamela M. Burrage | ... | Dan V. Nicolau
  • Special Issue
  • - Volume 2019
  • - Article ID 1253727
  • - Review Article

The Cancer Microbiota: EMT and Inflammation as Shared Molecular Mechanisms Associated with Plasticity and Progression

Daniele Vergara | Pasquale Simeone | ... | Marco Trerotola
  • Special Issue
  • - Volume 2019
  • - Article ID 8384913
  • - Review Article

Modulation of ERQC and ERAD: A Broad-Spectrum Spanner in the Works of Cancer Cells?

Gábor Tax | Andrea Lia | ... | Pietro Roversi
Journal of Oncology
 Journal metrics
Acceptance rate24%
Submission to final decision66 days
Acceptance to publication37 days
CiteScore1.400
Impact Factor2.206
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