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Membrane Transporters in Cancer

Call for Papers

The complex pathophysiology of cancer still remains a poorly understood area of biomedicine. Cancer pathogenesis involves dynamic genetic and/or epigenetic alterations that ultimately impair normal tissue homeostasis and drive the transformation of normal cells into malignant derivatives that exhibit uncontrolled and disorganized growth. Among the genes affected during malignant transformation, it is inevitable that those encoding membrane transporters are involved. Membrane transporters are encoded by numerous gene families. They move a wide range of endogenous and exogenous substrates across cellular and organelle membranes, including sugars, amino acids, nucleotides, hormones, neurotransmitters, inorganic ions, and xenobiotics.

Increasing evidence shows that membrane transporters are involved in many aspects of cancer biology and therapy. For example, studies showed that some membrane transporters could promote tumorigenesis, metastasis, and tumor cell survival in some cancers; they might serve as biomarkers for cancer diagnosis and prognosis; they might play important roles in cancer chemosensitivity and chemoresistance; they could mediate targeted anticancer drug delivery by some nanoparticles; and they could also act as drug targets for anticancer drug discovery and development. However, the function and role of membrane transporters in cancer are still largely unknown. With increasing importance of membrane transporters in cancer biology and therapeutics, more investigation in this area is urgently needed.

The aim of this special issue is to provide a platform for communicating cutting-edge research on all aspects related to membrane transporters in cancer. The scope is open to all related topics, including basic research, clinical research, and drug discovery and development. We invite and encourage authors working in the areas relevant to membrane transporters in cancer to submit their original research articles to this special issue. We also welcome review articles that describe any of the topics related to membrane transporters in oncology and cancer research

Potential topics include but are not limited to the following:

  • Membrane transporters in tumor cell proliferation, differentiation, migration, invasion, metastasis, and survival/apoptosis
  • Membrane transporters in tumor cell-microenvironment cross-talk
  • Membrane transporters in tumor angiogenesis
  • Membrane transporters in cancer chemosensitivity and chemoresistance
  • Membrane transporters as biomarkers for tumor diagnosis and prognosis
  • Membrane transporters as drug targets for cancer chemotherapy
  • Membrane transporter-based anticancer drug discovery and development
  • Membrane transporter-mediated anticancer drug delivery
  • Membrane transporters and cancer stem cells

Authors can submit their manuscripts through the Manuscript Tracking System at https://mts.hindawi.com/submit/journals/jo/mtc/.

Submission DeadlineFriday, 22 June 2018
Publication DateNovember 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

Guest Editors

  • Xingguo Cheng, St. John’s University, Queens, USA
  • Mei Hong, South China Agricultural University, Guangzhou, China