Chemotherapy is a well-known treatment to phase out and reduce cancer growth in many cases and is more effective compared to the other risk factors. Several chemotherapeutic medicines with different formulations are applicable which involve only chemotherapy medication, and association of surgery and radiotherapy based on the stages of cancer. However, it also has adverse effects on treatment recipients where advanced safety requirements are to be developed for the well-being of patients. Considering this circumstance, evolving nanoparticle-based drug delivery systems are analyzed to improve balancing, biocompatibility, permeability and retention effect, and accurate targeting. Recent applications and progression nanoparticles aid the drug-carrier system to promote to the next stage. Cancer crises are increasing endlessly, and an extensive focus should be on the accurate identification of drug administration routes for accomplishing effective treatment. Innovative applications and techniques in drug-delivery systems (DDS) are in huge demand to face the challenges of various medication routes of administration for attaining appropriate and optimal drug delivery solutions to the targeted cancer cells, bioavailability, pharmacokinetics, and biodistribution in order to modernize the cancer treatment methods, personalized healthcare management, potency and reduce toxicity. Nano-based drug delivery strategies for cancer therapy create increasing possibilities and the uptake of the chemotherapeutic agents through the cancer cells to efficiently mitigate the injurious impacts on other healthy organs.

Research has embarked on nano-drug delivery for treating cancer. Natural compounds present in plants, namely phytochemicals, have been extensively exploited for their anticancer properties. Despite their excellent anticancer abilities, phytochemicals are limited by their low water solubility and poor bioavailability. The phytochemicals were found to become more soluble when delivered by the nanocarriers and exhibited a remarkable effect on the cancer cells, compared to their free form. Nanoparticles targeting these mechanisms can pave the way for the development of the reversal of multidrug resistance. In addition, since numerous cancer drug resistance mechanisms are discovered, to efficiently target these mechanisms advancements are carried out in nanoparticles. Researchers are currently analyzing the performance of the nanoparticles in immunotherapy which has a more elevated place in cancer treatment.

This Special Issue aims to outline how the advent of nanotechnology has revolutionized various scientific inventions, out of which the debut of nanomedicine is outstanding. We welcome both original research and review articles.

Potential topics include but are not limited to the following:

• Natural products based on nano-drug delivery systems in antitumor chemotherapy
• Nano-based drug delivery systems for cancer chemoimmunotherapy
• Nanocarriers-mediated drug delivery systems for anticancer agents
• Transdermal drug delivery systems for cancer therapy
• Lipid-based nano-based delivery systems for melanoma therapy
• Liposomal drug delivery systems for prostate cancer therapy
• Hypoxia-specific nano-drug delivery systems for cancer therapy
• Nano-based drug delivery modalities for the treatment of cancer
• Nanocarriers in enhanced drug delivery for tumors
• Ideal drug delivery systems for breast cancer
• Evolving challenges and applications of drug-delivery systems and cancer theranostics
• Recent trends of polyoxometalates-based drug delivery systems in chemotherapy
• Impact of hyaluronic acid and gallic acid in advancing cancer chemotherapy