The Role of Lipid Metabolism in Tumor Progression
1Chongqing Medical University, Chongqing, China
2Union Hospital, Tongji Medical College, Wuhan, China
3The First Affiliated Hospital of Dalian Medical University, Dalian, China
4Thiruvalluvar University, Vellore, China
The Role of Lipid Metabolism in Tumor Progression
Description
Lipid metabolism is a very complex process, including processes such as lipid uptake, transportation, synthesis, and degradation. Lipid metabolism is regulated by a variety of biological signaling pathways and can produce a variety of intermediate products, most of which are lipid molecules with biological activity, such as fatty acids, diglycerides, ceramides, and cholesterol. These lipid molecules can act as a bridge between lipid metabolism and a variety of biological signal pathways, and then participate in the regulation of many biological behaviors in cells, such as cell growth, proliferation, differentiation, apoptosis, and biofilm homeostasis. The homeostasis of lipids is essential to the normal life activities of cells. Abnormal lipid metabolism can affect lipid levels, thereby changing the composition and permeability of biological membranes, affecting a variety of biological signal pathways, and leading to the occurrence and development of a variety of diseases, including tumors. Recent studies have also shown that abnormal lipid metabolism is regarded as an important factor affecting the occurrence and development of tumors. Changes in the composition, distribution, and content of lipids in tumor cells and cell membranes have also been regarded as the potential pathogenesis and progression mechanisms of many types of tumors.
Abnormal lipid metabolism has received more and more attention and made great achievements in the field of tumor research. For example, an abnormal increase in fatty acid de novo synthesis in tumor cells is a significant feature of tumorigenesis and development, and its abnormal activation is negatively correlated with the prognosis and disease-free survival of patients with various types of tumors. Therefore, targeting lipid metabolism in tumors is expected to become a new breakthrough in tumor treatment, and it is very urgent to identify new lipid metabolism-related biomarkers and explore the biological functions of these biomarkers.
This Special Issue welcomes original research and review articles to deepen our understanding of the field of lipid metabolism in tumors. An in-depth understanding of the molecular mechanism of lipid metabolism in the occurrence and development of tumors will help guide the clinical treatment of tumor patients, the development of new targeted drugs, and the prognostic research of tumor patients.
Potential topics include but are not limited to the following:
- Research progress of lipid metabolism-related genes in tumors
- Research progress of lipid metabolism-related drugs in tumors
- Research progress of abnormal lipid distribution in the drug resistance of tumors
- Regulation of lipid metabolism biological processes in the biological behavior of tumors
- The regulatory role of transcription factors in the lipid metabolism in tumors
- The regulatory role of microRNA in the lipid metabolism in tumors
- The regulatory role of long non-coding RNA in the lipid metabolism in tumors
- Regulatory role of traditional Chinese medicine molecules in the lipid metabolism in tumors
- Potential role of lipid metabolism-related molecules in chemotherapy for tumors or immunotherapy responses