Journal of Oncology

The Role of Lipid Metabolism in Tumor Progression


Publishing date
01 Mar 2023
Status
Closed
Submission deadline
21 Oct 2022

Lead Editor

1Chongqing Medical University, Chongqing, China

2Union Hospital, Tongji Medical College, Wuhan, China

3The First Affiliated Hospital of Dalian Medical University, Dalian, China

4Thiruvalluvar University, Vellore, China

This issue is now closed for submissions.

The Role of Lipid Metabolism in Tumor Progression

This issue is now closed for submissions.

Description

Lipid metabolism is a very complex process, including processes such as lipid uptake, transportation, synthesis, and degradation. Lipid metabolism is regulated by a variety of biological signaling pathways and can produce a variety of intermediate products, most of which are lipid molecules with biological activity, such as fatty acids, diglycerides, ceramides, and cholesterol. These lipid molecules can act as a bridge between lipid metabolism and a variety of biological signal pathways, and then participate in the regulation of many biological behaviors in cells, such as cell growth, proliferation, differentiation, apoptosis, and biofilm homeostasis. The homeostasis of lipids is essential to the normal life activities of cells. Abnormal lipid metabolism can affect lipid levels, thereby changing the composition and permeability of biological membranes, affecting a variety of biological signal pathways, and leading to the occurrence and development of a variety of diseases, including tumors. Recent studies have also shown that abnormal lipid metabolism is regarded as an important factor affecting the occurrence and development of tumors. Changes in the composition, distribution, and content of lipids in tumor cells and cell membranes have also been regarded as the potential pathogenesis and progression mechanisms of many types of tumors.

Abnormal lipid metabolism has received more and more attention and made great achievements in the field of tumor research. For example, an abnormal increase in fatty acid de novo synthesis in tumor cells is a significant feature of tumorigenesis and development, and its abnormal activation is negatively correlated with the prognosis and disease-free survival of patients with various types of tumors. Therefore, targeting lipid metabolism in tumors is expected to become a new breakthrough in tumor treatment, and it is very urgent to identify new lipid metabolism-related biomarkers and explore the biological functions of these biomarkers.

This Special Issue welcomes original research and review articles to deepen our understanding of the field of lipid metabolism in tumors. An in-depth understanding of the molecular mechanism of lipid metabolism in the occurrence and development of tumors will help guide the clinical treatment of tumor patients, the development of new targeted drugs, and the prognostic research of tumor patients.

Potential topics include but are not limited to the following:

  • Research progress of lipid metabolism-related genes in tumors
  • Research progress of lipid metabolism-related drugs in tumors
  • Research progress of abnormal lipid distribution in the drug resistance of tumors
  • Regulation of lipid metabolism biological processes in the biological behavior of tumors
  • The regulatory role of transcription factors in the lipid metabolism in tumors
  • The regulatory role of microRNA in the lipid metabolism in tumors
  • The regulatory role of long non-coding RNA in the lipid metabolism in tumors
  • Regulatory role of traditional Chinese medicine molecules in the lipid metabolism in tumors
  • Potential role of lipid metabolism-related molecules in chemotherapy for tumors or immunotherapy responses

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9736073
  • - Research Article

Regulatory Role of Fatty Acid Metabolism-Related Long Noncoding RNA in Prostate Cancer: A Computational Biology Study Analysis

Yutao Wang | Hao Su | ... | Hongjun Li
  • Special Issue
  • - Volume 2022
  • - Article ID 4705654
  • - Research Article

MSC Senescence-Related Genes Are Associated with Myeloma Prognosis and Lipid Metabolism-Mediated Resistance to Proteasome Inhibitors

Yang-Jia Cao | Yan-Hua Zheng | ... | Tian Li
  • Special Issue
  • - Volume 2022
  • - Article ID 6891655
  • - Research Article

Integrin α6 Indicates a Poor Prognosis of Craniopharyngioma through Bioinformatic Analysis and Experimental Validation

Yanfei Jia | Wentao Wu | ... | Tian Li
  • Special Issue
  • - Volume 2022
  • - Article ID 5233222
  • - Research Article

Correlation Study on the Expression of INSR, IRS-1, and PD-L1 in Nonsmall Cell Lung Cancer

Ma Ting | Yu-e Miao | ... | Jin Chang
  • Special Issue
  • - Volume 2022
  • - Article ID 4834791
  • - Research Article

Identification of Downregulated Exosome-Associated Gene ENPP1 as a Novel Lipid Metabolism and Immune-Associated Biomarker for Hepatocellular Carcinoma

Zhilan. Li | Qingchun. He | ... | Chencheng. Fu
  • Special Issue
  • - Volume 2022
  • - Article ID 4675683
  • - Research Article

The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer

Ying Liu | Yongbin Hu | Langmei Deng
  • Special Issue
  • - Volume 2022
  • - Article ID 6435431
  • - Research Article

Chelerythrine Inhibits Stemness of Cancer Stem-Like Cells of Osteosarcoma and PI3K/AKT/mTOR Signal

Zhixing Chen | Hui Yang | ... | Ziyi Zhao
  • Special Issue
  • - Volume 2022
  • - Article ID 7679652
  • - Research Article

Characterization of the Lipid Metabolism in Bladder Cancer to Guide Clinical Therapy

Yuan-Yuan Yang | Sen-Yuan Hong | ... | Shao-Gang Wang
  • Special Issue
  • - Volume 2022
  • - Article ID 9005804
  • - Research Article

Synergistic Lethality Effects of Apatinib and Homoharringtonine in Acute Myeloid Leukemia

Yuanfei Shi | Dandan Xu | ... | Wanzhuo Xie
  • Special Issue
  • - Volume 2022
  • - Article ID 6458877
  • - Review Article

The Regulatory Role of Lipid Metabolism in Endometrial Cancer

Shuyang Zhang | Xingyu Han
Journal of Oncology
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