Journal of Oncology

Cell Adhesion Signaling and Its Impact on Tumorigenesis


Publishing date
15 Aug 2010
Status
Published
Submission deadline
15 Feb 2010

Lead Editor

1Departments of Surgery and Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA

2Oncology Department, Faculty of Medicine, McGill University, Canada

3Laboratory for Biophotonics and Pharmacology, University of Strasbourg, 67401 Illkirch-Graffenstaden, France

4Discipline of Pediatrics and Child Health, The University of Sydney, Australia


Cell Adhesion Signaling and Its Impact on Tumorigenesis

Description

Loss of cell adhesion is a hallmark of cancer progression as it promotes cell migration and invasion leading to metastasis. This is attributed to many factors that regulate the process of cell invasion, thus, the influence of the tumor microenvironment and cell signaling has been recently emphasized. Cadherins have been implicated in signaling not only through changes in expression patterns, but also through the direct interaction with receptor tyrosine kinases. Integrins have long been known to play an important role in the transduction of signals from the extracellular matrix. Some members of the immunoglobulin superfamily, for example, certain CAMs, elicit an inflammatory or immune response, which has great implications for cancer progression. Furthermore, endothelial cell adhesion molecules affect processes such as angiogenesis.

Recent studies have not only implicated the interaction of cell adhesion molecules with other signaling molecules to be crucial for tumor initiation and progression, but also attributed signaling function to cell adhesion molecules and their cleavage products.

In this special issue, we invite authors to present original research articles as well as review articles that will highlight the current aspects of cell adhesion signaling in the context of tumorigenesis. Reviews may summarize complex signaling pathways regulated by cell adhesion molecules, new emerging principles of cell adhesion signaling, and mechanistic insights into cell adhesion and signal transduction. The implications for different types of tumors may be addressed. Furthermore, we welcome the presentation of model systems for the study of cell adhesion signaling in vitro as well as in vivo and other technical advances in the field.

Topics may include, but are not limited to:

  • Interaction of cell adhesion molecules with receptor-tyrosine kinases
  • Signaling function of cell adhesion molecule cleavage products
  • Induction of cell signaling through the microenvironment
  • Role of cadherins in epithelial-mesenchymal transition (EMT)
  • Gene expression changes in cell adhesion molecules that control signaling regulation
  • Adhesion signaling and reorganization of the actin cytoskeleton in metastatic cell migration
  • Adhesion-dependent cell polarization mechanisms in metastatic cells
  • Molecular mechanisms regulating integrin traffic
  • Analysis of adhesion signaling in three-dimensional culture systems
  • Adhesion signaling pathways as targets for novel anticancer approaches

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jo/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2010
  • - Article ID 257809
  • - Editorial

Cell Adhesion Signaling and Its Impact on Tumorigenesis

Claudia D. Andl | Ala-Eddin Al Moustafa | ... | Geraldine M. O'Neill
  • Special Issue
  • - Volume 2010
  • - Article ID 174715
  • - Review Article

The Misregulation of Cell Adhesion Components during Tumorigenesis: Overview and Commentary

Claudia D. Andl
  • Special Issue
  • - Volume 2010
  • - Article ID 107075
  • - Research Article

Lysophosphatidic Acid Upregulates Laminin-332 Expression during A431 Cell Colony Dispersal

Hironobu Yamashita | Manisha Tripathi | ... | Vito Quaranta
  • Special Issue
  • - Volume 2010
  • - Article ID 530130
  • - Research Article

Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV

Amber Yasmeen | Amal Alachkar | ... | Ala-Eddin Al Moustafa
  • Special Issue
  • - Volume 2010
  • - Article ID 932803
  • - Research Article

Hyperphosphorylated FAK Delocalizes from Focal Adhesions to Membrane Ruffles

Abdelkader Hamadi | Therese B. Deramaudt | ... | Philippe Rondé
  • Special Issue
  • - Volume 2010
  • - Article ID 232831
  • - Research Article

Tumor-Stromal Interactions Influence Radiation Sensitivity in Epithelial- versus Mesenchymal-Like Prostate Cancer Cells

Sajni Josson | Starlette Sharp | ... | Clayton Yates
  • Special Issue
  • - Volume 2010
  • - Article ID 541957
  • - Review Article

Claudin Family of Proteins and Cancer: An Overview

Amar B. Singh | Ashok Sharma | Punita Dhawan
  • Special Issue
  • - Volume 2010
  • - Article ID 363106
  • - Review Article

How Do Cells Make Decisions: Engineering Micro- and Nanoenvironments for Cell Migration

Siti Hawa Ngalim | Astrid Magenau | ... | Katharina Gaus
  • Special Issue
  • - Volume 2010
  • - Article ID 430142
  • - Review Article

Mesenchymal Migration as a Therapeutic Target in Glioblastoma

Jessie Zhong | Andre Paul | ... | Geraldine M. O'Neill
  • Special Issue
  • - Volume 2010
  • - Article ID 530745
  • - Research Article

Cleavage of E-Cadherin by Matrix Metalloproteinase-7 Promotes Cellular Proliferation in Nontransformed Cell Lines via Activation of RhoA

Conor C. Lynch | Tracy Vargo-Gogola | ... | Barbara Fingleton
Journal of Oncology
 Journal metrics
Acceptance rate24%
Submission to final decision66 days
Acceptance to publication37 days
CiteScore1.400
Impact Factor2.206
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