Journal of Oncology

The Involvement of RNA Interference in Cancer


Publishing date
01 Feb 2023
Status
Closed
Submission deadline
07 Oct 2022

Lead Editor
Guest Editors

1Wayne State University, Detroit, USA

2Duke University, Durham, USA

3University of Ioannina, Ioannina, Greece

This issue is now closed for submissions.

The Involvement of RNA Interference in Cancer

This issue is now closed for submissions.

Description

Since the first report of the RNA interference (RNAi) phenomenon in 1990, and the debut of the terminology and theory of RNAi on the center stage of science in 1998, RNAi pathways, including the exogenously synthesized small interfering RNAs (siRNAs) and short-hairpin RNAs (shRNAs), and the endogenously self-produced microRNAs (miRNAs) and other kinds of non-coding RNAs (ncRNAs), have been confirmed to cause gene silencing in various species. The techniques of sequencing, bioinformatic tools, and the public depository of various kinds of sequencing data lead to the discovery of more and more RNAi subjects (miRNAs, ncRNAs, siRNAs and shRNAs), their gene targets, and the extensive pathways they involve, forming a huge network regulated by different levels of feedback. The subjects found in RNAi are commonly seen participating in the pathogenesis, diagnosis, treatment, and prognosis of different kinds of cancer.

Thanks to the development of the above techniques and the cut-down in research costs, the number of miRNAs discovered has increased rapidly, as well as the discovery of other RNAi subjects, the pathways they involve, and their roles in different species and diseases. Therefore, it is of significant importance to keep up with the new findings in this hot research field so as to provide new clues for the clinical applications of RNAi.

The purpose of this Special Issue is to collate the latest updates in basic, translational, pharmacological, and clinical research on the comprehensive roles of RNAi in cancer-regulating gene modification, cancer cell origination, surveillance, proliferation, migration, invasion, and metastasis, as well as the diagnosis, prognosis, treatment, and drug resistance of clinical cases. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Cancer-regulating gene modification using RNAi
  • Novel techniques to discover and analyze RNAi subjects and their gene targets
  • Comparison of efficiency and toxicity of techniques to deliver RNAs into cells and the off-target effects
  • The role and application of extracellular vesicles in cancer
  • RNAi in cancer stem cells
  • RNAi mechanisms in cancer cell proliferation, metastasis, and cancer recurrence
  • RNAi in cancer immune regulation and inflammatory response
  • RNAi in the diagnosis, prognosis, treatment, and drug development and resistance of cancer cases
  • RNAi in other important and novel aspects of cancer

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9839681
  • - Retraction

Retracted: PRR15 Is a Novel Diagnostic and Prognostic Biomarker in Papillary Thyroid Cancer and Modulates the Tumor Microenvironment

Journal of Oncology
  • Special Issue
  • - Volume 2023
  • - Article ID 9813986
  • - Retraction

Retracted: SFRP2 is a Novel Diagnostic Biomarker and Suppresses the Proliferation of Pituitary Adenoma

Journal of Oncology
  • Special Issue
  • - Volume 2023
  • - Article ID 9832530
  • - Retraction

Retracted: Efficacy Evaluation of Inflammatory Mediators in the Treatment of Multiple Myeloma with Daratumumab

Journal of Oncology
  • Special Issue
  • - Volume 2023
  • - Article ID 3876342
  • - Research Article

HKDC1 Silencing Inhibits Proliferation and Glycolysis of Gastric Cancer Cells

Chen Yu | Ting-ting Bao | ... | Ji-feng Feng
  • Special Issue
  • - Volume 2023
  • - Article ID 2258906
  • - Research Article

Integrated Analyses of the Expression and Prognostic Value of EPHB6 in Cervical Cancer and Its Correlation with Immune Infiltrates

Siyang Xiang | Mei Wei | ... | Zhengai Xiong
  • Special Issue
  • - Volume 2023
  • - Article ID 7671917
  • - Research Article

LncRNA LINC01207 Could Positively Regulate the Development of Colorectal Cancer

Gaowu Hu | Wenquan Chen | ... | Yongqing Cao
  • Special Issue
  • - Volume 2023
  • - Article ID 1624580
  • - Research Article

Construction of a Novel Diagnostic Model Based on Ferroptosis-Related Genes for Hepatocellular Carcinoma Using Machine and Deep Learning Methods

Shiming Yi | Chunlei Zhang | ... | Jiafeng Wang
  • Special Issue
  • - Volume 2023
  • - Article ID 6544042
  • - Research Article

miR-4757-3p Inhibited the Migration and Invasion of Lung Cancer Cell via Targeting Wnt Signaling Pathway

Pei Zhao | Qian Zhao | ... | Li Jin
  • Special Issue
  • - Volume 2023
  • - Article ID 4732242
  • - Research Article

Comprehensive Analysis of Transcriptomic Profiles Identified the Prediction of Prognosis and Drug Sensitivity of Aminopeptidase-Like 1 (NPEPL1) for Clear Cell Renal Cell Carcinoma

Xiaoyu Wei | Zhongbao Zhou | ... | Fengze Sun
  • Special Issue
  • - Volume 2023
  • - Article ID 2205083
  • - Research Article

Comprehensive Molecular Analyses of Notch Pathway-Related Genes to Predict Prognosis and Immunotherapy Response in Patients with Gastric Cancer

Yinsen Song | Na Gao | ... | Baojun Zhang
Journal of Oncology
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