Journal of Oncology

Metastasis: Genetics, Mechanism, and Diagnostic and Therapeutic Strategies


Publishing date
15 Apr 2012
Status
Published
Submission deadline
15 Oct 2011

Lead Editor

1Departments of Medical Genetics and Otorhinolaryngology, Faculty of Medicine, Fatih University, Istanbul, Turkey

2Department of Medical Genetics, Faculty of Medicine, Fatih University, Istanbul, Turkey

3Department of Otorhinolaryngology, Wakayama Medical University, Wakayamashi, Japan

4Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

5Department of Molecular Biology and Biochemistry, Okayama University, Okayama, Japan

6Prostate Cancer/Genitourologic Program, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA

7Department of Otorhinolaryngology, University of Turku and Turku University Hospital, Turku, Finland


Metastasis: Genetics, Mechanism, and Diagnostic and Therapeutic Strategies

Description

Tumor masses are composed of heterogenic subpopulations of cancer cells, and cancer stem cell theory suggests that only a specific subpopulation of these cells has the ability to sustain cancer growth and metastatic activity, whereas all of the other cancer cells have only a limited growth potential or no growth potential at all. Based on this concept in the literature, to define the aggressiveness of a tumor, examination of the molecular characteristics of metastatic cell populations is a logical way as representatives of cancer stem cells.

The poor outcome in cancer patients has mainly been attributed to local and distant lymph node metastasis as well as recurrence. The ability to assess or predict the presence of metastasis has significant prognostic relevance and treatment implications in the management of cancer. In order to decrease morbidity and mortality from cancer, it is necessary to gain a greater understanding of metastasis and define the molecular factors that contribute to this process.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand metastasis and the development of strategies to early diagnose and treat these conditions. This special issue will mainly deal with general mechanism of metastasis, etiology, and treatment strategies but not with their roles in specific cancer types. However, when the article is being prepared, the topics (such as mechanism, genetics, etiology, and diagnostic as well as treatment strategies) can be discussed according to the cancer types. Potential topics include, but are not limited to:

  • Molecular mechanism of metastasis
  • Prognostic biomarkers and early diagnosis of metastasis
  • Molecular and targeted therapeutic strategies for metastasis
  • Role of SNPs, CNVs, and other polymorphisms in metastasis
  • Cancer stem cell model system in metastasis
  • Role of tumor and metastasis suppressor genes
  • Metastasis and microenvironment
  • Microarray and metastasis

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jo/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 390835
  • - Editorial

Metastasis: Genetics, Mechanism, and Diagnostic and Therapeutic Strategies

Mehmet Gunduz | Esra Gunduz | ... | Reidar Grenman
  • Special Issue
  • - Volume 2012
  • - Article ID 647684
  • - Clinical Study

Metastatic Behavior in Melanoma: Timing, Pattern, Survival, and Influencing Factors

Faruk Tas
  • Special Issue
  • - Volume 2012
  • - Article ID 413256
  • - Clinical Study

Salivary Protein Profiles among HER2/neu-Receptor-Positive and -Negative Breast Cancer Patients: Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression

Charles F. Streckfus | Daniel Arreola | ... | Lenora Bigler
  • Special Issue
  • - Volume 2012
  • - Article ID 796729
  • - Research Article

Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/β-Catenin Pathways

Lulu Farhana | Marcia I. Dawson | ... | Joseph A. Fontana
  • Special Issue
  • - Volume 2012
  • - Article ID 853797
  • - Review Article

Dual Roles of METCAM in the Progression of Different Cancers

Guang-Jer Wu
  • Special Issue
  • - Volume 2012
  • - Article ID 651507
  • - Research Article

Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density

Patricia E. Ellis | Allan B. MacLean | ... | Christopher W. Perrett
  • Special Issue
  • - Volume 2012
  • - Article ID 723541
  • - Review Article

The Molecular Biology of Brain Metastasis

Gazanfar Rahmathulla | Steven A. Toms | Robert J. Weil
  • Special Issue
  • - Volume 2012
  • - Article ID 340380
  • - Review Article

A Proposal of a Practical and Optimal Prophylactic Strategy for Peritoneal Recurrence

Masafumi Kuramoto | Shinya Shimada | ... | Hideo Baba
Journal of Oncology
 Journal metrics
Acceptance rate33%
Submission to final decision93 days
Acceptance to publication48 days
CiteScore3.220
Impact Factor2.600
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