Research Article

Racial Disparities between the Sex Steroid Milieu and the Metabolic Risk Profile

Table 1

Comparison of subject characteristics between CA and AA women using student’s t-tests for unpaired samples.

CharacteristicsCA women (n=36)AA women (n=30)Pa

Age (y)    41.94±7.10    37.97±9.94.063
Height (m)        1.64±0.07        1.62±0.06.168
Weight (kg)    94.79±15.72    91.84±14.03.427
BMI (kg/m2)    35.12±5.35    34.88±4.4.850
Resting heart rate (beats/min)    73.67±11.04    76.57±10.90.289
Stressb    67.71±21.37    69.28±31.64.815
Educationc        2.56±0.50        2.30±0.66.077
Physical activity (kcal/wk)983.65±1,033.60892.88±895.74.723
Cigarettes (no./d)        2.11±6.96        1.53±5.10.707
Alcohol        5.56±13.78        2.27±5.65.226
Metabolic risk profile
Waist (cm)107.29±14.50101.03±11.27.058
WHR0.86±0.060.87±0.08.536
SAT (L)        4.68±1.28        4.51±1.40.603
VAT (L)        1.20±0.48        0.76±0.30<.001
Glucose (mmol/L)d        4.80±0.57        4.76±5.77.758
Insulin (μU/mL)    14.84±8.13    14.75±5.77.957
HOMA IR        3.13±1.81        3.20±1.39.878
Systolic blood pressure (mmHg)126.67±14.89123.00±14.21.313
Diastolic blood pressure (mmHg)    82.11±10.13    82.20±8.70.970
Triglycerides (mg/dL)144.50±78.44107.77±67.58.048
Total cholesterol (mmol/L)5.34±1.32  5.14±1.41.552
HDL (mmol/L)1.44±0.42        1.45±0.29.931
HDL2 (mmol/L)0.36±0.23        0.41±0.28.428e
LDL (mmol/L)        3.10±0.96        3.13±1.25.909
LDL pps (nmol/L)    27.11±0.71    27.15±0.57.799
Apo B (mg/dL)106.50±29.22102.70±30.69.609
Total cholesterol/HDL        3.91±1.26        3.69±1.35.488
Lp(a) (mg/dL)    24.86±20.60      36.85±23.59.093
SHBG and Sex Steroids
SHBG (nmol/L)e    33.88±22.9843.80±30.73.073e
TT (ng/mL)e        0.27±0.11        0.33±0.19.170e
FAI        4.24±3.55        4.11±4.83.685e

Values are means ± SD. SAT indicates volume of subcutaneous adipose tissue; VAT indicates volume of visceral adipose tissue; IR, insulin resistance calculated as (insulin, μU/mL × glucose, mmol/L) ÷ 22.5; HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; LDL pps-low-density lipoprotein, peak particle size; Apo B, apolipoprotein B; SHBG, sex hormone binding globulin; TT, total testosterone, FAI, free androgen index, calculated as TT (ng/mL) × 3.467 × 100/SHBG (nmol/L).
aValues obtained from a Student’s t-test for unpaired samples.
bGraded numerically, with the higher number indicating a higher stress level.
cGraded on a scale of 1 to 5, with the higher number indicating a higher level of education.
dOne outlier was excluded from the analysis.
et-test performed on transformed values.