Journal of Obesity / 2010 / Article / Tab 2

Research Article

Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study

Table 2

Association of the TT and CT genotypes of the TCF7L2 rs7903146 gene variant with the incidence of coronary heart disease in categories of BMI. Cox proportional hazard analyses were performed with age at time of event as the time variable and adjustment for gender and ARIC study center. For the total sample and in race strata, the referent category was individuals with BMI < 25 kg/m2 carrying the CC genotype of the TCF7L2 rs7903146 gene variant.

Total sample  (n=13,496)Whites (n=9,865)Blacks  (n=3,631)
CCCTTTCCCTTTCCCTTT
(n=6,736)(n=5,583)(n=1,177)(n=4,927)(n=4,063)(n=875)(n=1,809)(n=1,520)(n=302)

Events88371717269155112919216643
p-years100,43582,89917,38474,42161,05313,11226,01521,8464,272
HR (95% CI)1.021.111.001.071.081.24
1.00(0.92, 1.12)(0.94, 1.31)1.00(0.89, 1.11)(0.89, 1.30)1.00(0.88, 1.33)(0.89, 1.72)

BMI categories:
BMI<25
(n=4,476)
Events210159551751244735358
p-years33,08328,20066,03327,85023,5775,1345,2324,629900
HR (95% CI)0.901.400.821.421.311.26
1.00(0.74, 1.11)(1.04, 1.88)1.00(0.65, 1.04)(1.03, 1.97)1.00(0.82, 2.09)(0.58, 2.71)

BMI 25–30
(n=5,325)
Events3943206732426052706015
p-years39,30932,9186,98929,44624,4545,3999,8628,4641,590
HR (95% CI)1.331.311.281.311.281.181.221.251.55
(1.12, 1.57)(1.10, 1.56)(0.97, 1.69)(1.09, 1.58)(1.06, 1.56)(0.86, 1.61)(0.81, 1.83)(0.82, 1.89)(0.85, 2.85)

BMI 30
(n=3,695)
Events2792385019216730877120
p-years28,04521,7764,36117,12413,0232,57910,9208,7531,782
HR (95% CI)1.611.851.891.561.951.711.571.532.02
(0.35, 1.93)(1.53, 2.23)(1.39, 2.57)(0.27, 1.91)(1.58, 2.41)(1.16, 2.53)(1.06, 2.34)(1.01, 2.30)(1.16, 3.51)

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