Role of BMI in the Association of the TCF7L2 rs7903146 Variant with Coronary Heart Disease: The Atherosclerosis Risk in Communities (ARIC) Study

Table 2

Association of the TT and CT genotypes of the TCF7L2 rs7903146 gene variant with the incidence of coronary heart disease in categories of BMI. Cox proportional hazard analyses were performed with age at time of event as the time variable and adjustment for gender and ARIC study center. For the total sample and in race strata, the referent category was individuals with BMI $<$ 25 kg/m² carrying the CC genotype of the TCF7L2 rs7903146 gene variant.

	Total sample$\mathrm{\hspace{0.17em}\hspace{0.17em}}(n=\mathrm{13,496})$			Whites $(n=\mathrm{9,865})$			Blacks$\mathrm{\hspace{0.17em}\hspace{0.17em}}(n=\mathrm{3,631})$
	CC	CT	TT	CC	CT	TT	CC	CT	TT
	$(n=\mathrm{6,736})$	$(n=\mathrm{5,583})$	$(n=\mathrm{1,177})$	$(n=\mathrm{4,927})$	$(n=\mathrm{4,063})$	$(n=875)$	$(n=\mathrm{1,809})$	$(n=\mathrm{1,520})$	$(n=302)$
Events	883	717	172	691	551	129	192	166	43
p-years	100,435	82,899	17,384	74,421	61,053	13,112	26,015	21,846	4,272
HR (95% CI)		1.02	1.11		1.00	1.07		1.08	1.24
	1.00	(0.92, 1.12)	(0.94, 1.31)	1.00	(0.89, 1.11)	(0.89, 1.30)	1.00	(0.88, 1.33)	(0.89, 1.72)
BMI categories:
BMI$\hspace{0.17em}\hspace{0.17em}<\hspace{0.17em}\hspace{0.17em}$25
$(n=\mathrm{4,476})$
Events	210	159	55	175	124	47	35	35	8
p-years	33,083	28,2006	6,033	27,850	23,577	5,134	5,232	4,629	900
HR (95% CI)		0.90	1.40		0.82	1.42		1.31	1.26
	1.00	(0.74, 1.11)	(1.04, 1.88)	1.00	(0.65, 1.04)	(1.03, 1.97)	1.00	(0.82, 2.09)	(0.58, 2.71)
BMI 25–30
$(n=\mathrm{5,325})$
Events	394	320	67	324	260	52	70	60	15
p-years	39,309	32,918	6,989	29,446	24,454	5,399	9,862	8,464	1,590
HR (95% CI)	1.33	1.31	1.28	1.31	1.28	1.18	1.22	1.25	1.55
	(1.12, 1.57)	(1.10, 1.56)	(0.97, 1.69)	(1.09, 1.58)	(1.06, 1.56)	(0.86, 1.61)	(0.81, 1.83)	(0.82, 1.89)	(0.85, 2.85)
BMI $\ge$30
$(n=\mathrm{3,695})$
Events	279	238	50	192	167	30	87	71	20
p-years	28,045	21,776	4,361	17,124	13,023	2,579	10,920	8,753	1,782
HR (95% CI)	1.61	1.85	1.89	1.56	1.95	1.71	1.57	1.53	2.02
	(0.35, 1.93)	(1.53, 2.23)	(1.39, 2.57)	(0.27, 1.91)	(1.58, 2.41)	(1.16, 2.53)	(1.06, 2.34)	(1.01, 2.30)	(1.16, 3.51)