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Journal of Obesity
Volume 2010, Article ID 892081, 10 pages
http://dx.doi.org/10.1155/2010/892081
Research Article

Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents

1Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China
2Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
3Centre de Recherche Institut, Universitaire de Cardiologie et Pneumologie de Quebec, Université Laval, 2725 Chemin Ste-Foy, Québec, QC, Canada G1V 4G5
4Laboratory of Nutrition and Nutritional Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Received 25 June 2010; Accepted 6 September 2010

Academic Editor: Paul Trayhurn

Copyright © 2010 Jie Mi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents. Methods. Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents ( , 6–18 years, 1722 girls and 1783 boys). Results. Leptin concentration increased while adiponectin decreased with obesity, both were influenced by pubertal development. Central obesity had an additive effect on leptin levels (above obesity alone). Leptin/adiponectin increased 8.4-fold and 3.2-fold in overweight/obesity, and 15.8- and 4.5-fold with obesity plus MS, in early and late puberty, respectively. Even in normal weight children/adolescents, higher leptin and lower adiponectin concentrations associated with increased risk profile. Conversely, overweight/obese with lower leptin or higher adiponectin concentrations had a less compromised metabolic profile. Conclusion. Leptin, adiponectin, and leptin:adiponectin ratio are informative biomarkers for obesity, central obesity, MS, and abnormal metabolic profile even in normal weight children/adolescents.