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Journal of Obesity
Volume 2010, Article ID 892081, 10 pages
http://dx.doi.org/10.1155/2010/892081
Research Article

Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents

1Department of Epidemiology, Capital Institute of Pediatrics, Beijing 100020, China
2Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
3Centre de Recherche Institut, Universitaire de Cardiologie et Pneumologie de Quebec, Université Laval, 2725 Chemin Ste-Foy, Québec, QC, Canada G1V 4G5
4Laboratory of Nutrition and Nutritional Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Received 25 June 2010; Accepted 6 September 2010

Academic Editor: Paul Trayhurn

Copyright © 2010 Jie Mi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-F. Fu, L. Liang, C.-C. Zou et al., “Prevalence of the metabolic syndrome in Zhejiang Chinese obese children and adolescents and the effect of metformin combined with lifestyle intervention,” International Journal of Obesity, vol. 31, no. 1, pp. 15–22, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Y. Ji and T. O. Cheng, “Epidemic increase in overweight and obesity in Chinese children from 1985 to 2005,” International Journal of Cardiology, vol. 132, no. 1, pp. 1–10, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. B. M. Y. Cheung, N. M. S. Wat, S. Tam et al., “Components of the metabolic syndrome predictive of its development: a 6-year longitudinal study in Hong Kong Chinese,” Clinical Endocrinology, vol. 68, no. 5, pp. 730–737, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. W. D.Johnson, J. J. M. Kroon, F. L. Greenway, C. Bouchard, D. Ryan, and P. T. Katzmarzyk, “Prevalence of risk factors for metabolic syndrome in adolescents: national health and nutrition examination survey (NHANES), 2001–2006,” Archives of Pediatrics and Adolescent Medicine, vol. 163, no. 4, pp. 371–377, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. Q. Zhuo, Z. Wang, P. Fu et al., “Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities,” Diabetes Research and Clinical Practice, vol. 84, no. 1, pp. 27–33, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. C. B. Jasik and R. H. Lustig, “Adolescent obesity and puberty: the “perfect storm”,” Annals of the New York Academy of Sciences, vol. 1135, pp. 265–279, 2008. View at Publisher · View at Google Scholar
  7. B. Antuna-Puente, B. Feve, S. Fellahi, and J.-P. Bastard, “Adipokines: the missing link between insulin resistance and obesity,” Diabetes and Metabolism, vol. 34, no. 1, pp. 2–11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. A. M. G. Cali and S. Caprio, “Obesity in children and adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. S31–S36, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. I. R. Madeira, C. N. M. Carvalho, F. M. Gazolla, L. W. Pinto, M. A. Borges, and M. A. N. Bordallo, “Impact of obesity on metabolic syndrome components and adipokines in prepubertal children,” Jornal de Pediatria, vol. 85, no. 3, pp. 261–268, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Okamoto, S. Kihara, T. Funahashi, Y. Matsuzawa, and P. Libby, “Adiponectin: a key adipocytokine in metabolic syndrome,” Clinical Science, vol. 110, no. 3, pp. 267–278, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. M. E. Trujillo and P. E. Scherer, “Adiponectin—journey from an adipocyte secretory protein to biomarker of the metabolic syndrome,” Journal of Internal Medicine, vol. 257, no. 2, pp. 167–175, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. J. C. Winer, T. L. Zern, S. E. Taksali et al., “Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 11, pp. 4415–4423, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Fang and G. Sweeney, “Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes,” Biochemical Society Transactions, vol. 34, no. 5, pp. 798–801, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Shargorodsky, M. Boaz, Y. Goldberg et al., “Adiponectin and vascular properties in obese patients: is it a novel biomarker of early atherosclerosis?” International Journal of Obesity, vol. 3, no. 5, pp. 553–558, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. E. Jéquier, “Leptin signaling, adiposity, and energy balance. Lipids and Insulin Resistance: the Role of Fatty Acid Metabolism and Fuel Partitioning,” Annals of the New York Academy of Sciences, vol. 967, pp. 379–388, 2002. View at Google Scholar
  16. O. Moran and M. Phillip, “Leptin: obesity, diabetes and other peripheral effects—a review,” Pediatric Diabetes, vol. 4, no. 2, pp. 101–109, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. C.-C. Liao, T.-C. Su, K.-L. Chien et al., “Elevated blood pressure, obesity, and hyperlipidemia,” Journal of Pediatrics, vol. 155, no. 1, pp. 79–83, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. Y. Wu, “Overweight and obesity in China,” British Medical Journal, vol. 333, no. 7564, pp. 362–363, 2006. View at Google Scholar · View at Scopus
  19. P. B. Kaplowitz, “Link between body fat and the timing of puberty,” Pediatrics, vol. 121, supplement 3, pp. S208–S217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. L. A. Moreno, C. Tomás, M. González-Gross, G. Bueno, J. M. Pérez-González, and M. Bueno, “Micro-environmental and socio-demographic determinants of childhood obesity,” International Journal of Obesity, vol. 28, supplement 3, pp. S16–S20, 2004. View at Publisher · View at Google Scholar
  21. A. Körner, S. Blüher, T. Kapellen et al., “Obesity in childhood and adolescence: a review in the interface between adipocyte physiology and clinical challenges,” Hormones, vol. 4, no. 4, pp. 189–199, 2005. View at Google Scholar · View at Scopus
  22. F. Eyzaguirre and V. Mericq, “Insulin resistance markers in children,” Hormone Research, vol. 71, no. 2, pp. 65–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. L. A. Moreno, I. Pineda, G. Rodríguez et al., “Leptin and metabolic syndrome in obese and non-obese children,” Hormone and Metabolic Research, vol. 34, no. 7, pp. 394–399, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Q. Shaibi, M. L. Cruz, M. J. Weigensberg et al., “Adiponectin independently predicts metabolic syndrome in overweight Latino youth,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 5, pp. 1809–1813, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Steinberger, L. Steffen, D. R. Jacobs Jr., A. Moran, C.-P. Hong, and A. R. Sinaiko, “Relation of leptin to insulin resistance syndrome in children,” Obesity Research, vol. 11, no. 9, pp. 1124–1130, 2003. View at Google Scholar · View at Scopus
  26. R. Nishimura, H. Sano, T. Matsudaira et al., “Changes in body mass index, leptin and adiponectin in Japanese children during a three-year follow-up period: a population-based cohort study,” Cardiovascular Diabetology, vol. 8, article 30, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Zhang, X. Liu, W. J. Brickman et al., “Association of plasma leptin concentrations with adiposity measurements in rural Chinese adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 9, pp. 3497–3504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. N. Oda, S. Imamura, T. Fujita et al., “The ratio of leptin to adiponectin can be used as an index of insulin resistance,” Metabolism: Clinical and Experimental, vol. 57, no. 2, pp. 268–273, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. N. Satoh, M. Naruse, T. Usui et al., “Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients,” Diabetes Care, vol. 27, no. 10, pp. 2488–2490, 2004. View at Publisher · View at Google Scholar · View at Scopus
  30. O. A. Mojiminiyi, N. A. Abdella, M. Al Arouj, and A. Ben Nakhi, “Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with Type 2 diabetes,” International Journal of Obesity, vol. 31, no. 2, pp. 213–220, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. C. Koebnick, G. Q. Shaibi, L. A. Kelly et al., “Leptin-to-adiponectin ratio as independent predictor of insulin sensitivity during growth in overweight Hispanic youth,” Journal of Endocrinological Investigation, vol. 30, no. 7, pp. RC13–RC16, 2007. View at Google Scholar · View at Scopus
  32. M. Li, A. Fisette, X.-Y. Zhao, J.-Y. Deng, J. Mi, and K. Cianflone, “Serum resistin correlates with central obesity but weakly with insulin resistance in Chinese children and adolescents,” International Journal of Obesity, vol. 33, no. 4, pp. 424–439, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. T. J. Cole, M. C. Bellizzi, K. M. Flegal, and W. H. Dietz, “Establishing a standard definition for child overweight and obesity worldwide: international survey,” British Medical Journal, vol. 320, no. 7244, pp. 1240–1243, 2000. View at Google Scholar · View at Scopus
  34. L. Ming, W. Congyuan, S. Ailing, and Z. Kui, “Development and preliminary application of enzyme-linked immunosorbent assay for human net insulin in serum,” The Journal of Clinical Endocrinology & Metabolism, vol. 13, pp. 214–217, 1997. View at Google Scholar
  35. K. Zhang, M. Li, and C. Y. Wu, “reparation of antibodies against human leptin and evelopement on new generation ELISA for human serum leptin,” Hong Kong Medical Journal, vol. 7, supplement 2, pp. 139–139, 2001. View at Google Scholar
  36. N. J. Wan, J. Mi, T. Y. Wang et al., “Metabolic syndrome in overweight and obese school children in Beijing,” Zhonghua Er Ke Za Zhi, vol. 6, pp. 417–421, 2007. View at Google Scholar
  37. V. M. Cambuli, M. C. Musiu, M. Incani et al., “Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 8, pp. 3051–3057, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Kettaneh, B. Heude, J.-M. Oppert et al., “Serum adiponectin is related to plasma high-density lipoprotein cholesterol but not to plasma insulin-concentration in healthy children: the FLVS II study,” Metabolism: Clinical and Experimental, vol. 55, no. 9, pp. 1171–1176, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Nagel, K. Rapp, M. Wabitsch et al., “Prevalence and cluster of cardiometabolic biomarkers in overweight and obese schoolchildren: results from a large survey in Southwest Germany,” Clinical Chemistry, vol. 54, no. 2, pp. 317–325, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Yoshinaga, K. Sameshima, Y. Tanaka et al., “Adipokines and the prediction of the accumulation of cardiovascular risk factors or the presence of metabolic syndrome in elementary school children,” Circulation Journal, vol. 72, no. 11, pp. 1874–1878, 2008. View at Publisher · View at Google Scholar · View at Scopus