Research Article

Differential Effects of Calorie Restriction and Exercise on the Adipose Transcriptome in Diet-Induced Obese Mice

Table 2

Transcriptional changes in response to calorie restriction or exercise in visceral white adipose tissue.

Gene SymbolGene titleFold change

Cellular lipid metabolic processCR × DIO
Slc27a1Solute carrier family 27 (fatty acid transporter)2.53up
Fads2Fatty acid desaturase 22.18up
Ces3Carboxylesterase 32.51up
Sult1a1Sulfotransferase family 1A2.22up
PtgesProstaglandin E synthase2.25up
Sgpp1Sphingosine-1-phosphate phosphatase 12.73down
Echs1Enoyl Coenzyme A hydratase2.00up
Hsd11b1Hydroxysteroid 11-beta dehydrogenase 13.28up
Apoc3Apolipoprotein C-III5.71up
Srebf1*Sterol regulatory element binding transcription factor 12.98up
Aldh1a7Aldehyde dehydrogenase family 12.18up
HpgdHydroxyprostaglandin dehydrogenase 15 (NAD)2.09down
Rdh11Retinol dehydrogenase 114.59up
Rarres2Retinoic acid receptor responder (tazarotene induced) 22.61down
Nsdhl*NAD(P) dependent steroid dehydrogenase-like2.65up
GpamGlycerol-3-phosphate acyltransferase2.06up
Hmgcs1*3-hydroxy-3-methylglutaryl-Coenzyme A synthase 13.01down
Abat4-aminobutyrate aminotransferase2.88down
Sorl1Sortilin-related receptor2.77up
Pip4k2aPhosphatidylinositol-5-phosphate 4-kinase2.02down
AcacaAcetyl-Coenzyme A carboxylase alpha4.60up
Tm7sf2*Transmembrane 7 superfamily member 23.69up
Sc5d*Sterol-C5-desaturase2.11up
Fdft1*Farnesyl diphosphate farnesyl transferase 12.68up
Hsd17b12*Hydroxysteroid (17-beta) dehydrogenase 122.17up
Pcx*Pyruvate carboxylase2.88up

Cellular carbohydrate metabolic process
Fn3kFructosamine 3 kinase4.05up
Chst1*Carbohydrate (keratan sulfate Gal-6) sulfotransferase 12.00up
DlatDihydrolipoamide S-acetyltransferase2.59up
Pkm2Pyruvate kinase2.37up
Pmm1Phosphomannomutase 12.72up
Ppp1r1aProtein phosphatase 12.61up
PgdPhosphogluconate dehydrogenase2.40up
AglAmylo-12.16up
Oxct13-oxoacid CoA transferase 12.17down
Pdk1Pyruvate dehydrogenase kinase3.07up
Gpd1Glycerol-3-phosphate dehydrogenase 1 (soluble)2.02up
Taldo1Transaldolase 12.03up

Glucose transport
Sh2b2*SH2B adaptor protein 23.26up
Slc2a4Solute carrier family 2 (facilitated glucose transporter)3.43up
Pcx*Pyruvate carboxylase2.88up
Klf15Kruppel-like factor 152.36up

Immune responseCR × DIO
Malt1Mucosa associated lymphoid tissue Lymphoma translocation gene 12.55down
Bcl6*B-cell leukemia/lymphoma 62.90down
Clec7a*C-type lectin domain family 72.89down
CfbComplement factor B2.53down
Cd55*CD55 antigen2.25Down
Thy1Thymus cell antigen 12.44down

Biosynthesis of Steroids
LssLanosterol synthase2.13up
Hmgcs1*3-hydroxy-3-methylglutaryl-Coenzyme A synthase 13.01down
Tm7sf2*Transmembrane 7 superfamily member 23.69up
Sc5d*Sterol-C5-desaturase2.11up
Fdft1*Farnesyl diphosphate farnesyl transferase 12.68up
Hsd17b12*Hydroxysteroid (17-beta) dehydrogenase 122.17up
Nsdhl*NAD(P) dependent steroid dehydrogenase-like2.65up
Sh2b2*SH2B adaptor protein 23.26up

Stress response
Thbs1Thrombospondin 12.29down
Tfpi2Tissue factor pathway inhibitor 24.32down
Gp1bbGlycoprotein Ib2.06up
Taok3TAO kinase 32.21down
Sod3Superoxide dismutase 32.17down
Dusp10Dual specificity phosphatase 102.62down
Adrb3Adrenergic receptor2.09up
F2rCoagulation factor II (thrombin) receptor2.22down
Ccnd1Cyclin D12.91down
EvlEna-vasodilator stimulated phosphoprotein2.32down
CtsbCathepsin B2.00down
Ly86Lymphocyte antigen 862.65down
Fabp4Fatty acid binding protein 42.03up
Rad50RAD50 homolog (S. cerevisiae)2.27down
Tsc22d2TSC22 domain family 22.41down
Ptger3Prostaglandin E receptor 3 (subtype EP3)2.21up
Lcp1Lymphocyte cytosolic protein 13.06down
Pros1Protein S (alpha)2.09down
Hspa12aHeat shock protein 12A2.40down
Anxa2Annexin A22.01down
Uhrf1Ubiquitin-like2.84down
Cdkn1aCyclin-dependent kinase inhibitor 1A (P21)2.28down
Srebf1*Sterol regulatory element binding transcription factor 12.98up
Chst1*Carbohydrate (keratan sulfate Gal-6) sulfotransferase 12.00up
Bcl6*B-cell leukemia/lymphoma 62.90down
Clec7a*C-type lectin domain family 72.89down
Cd55*CD55 antigen2.25down

Exercise unique
Mitochondrial TransportEX × DIO
Ucp1Uncoupling protein8.94up
Ucp2Uncoupling protein 22.09down

*Genes represented in two different categories.