An Obesity Risk SNP (rs17782313) near the MC4R Gene Is Associated with Cerebrocortical Insulin Resistance in Humans
Figure 1
Insulin effect on theta activity in the genotype groups: in subjects carrying the rare allele of rs17782313 in the homozygous (TC) or the heterozygous form (CC), the effect of insulin on theta activity was significantly reduced as compared to carriers of the wild-type allele (TT) . The diamonds show the means of each group (horizontal line) and the confidence intervals of the means (upper and lower point). The effect of the genotype remained significant after adjusting for BMI and also after adjusting for BMI and peripheral insulin sensitivity .
