Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier

Table 3

Interactions between FTO and MC4R SNPs and rural/urban dwelling in associations with obesity traits.

	rs9939609			rs17782313
	Coeff^a	95% CI	𝑃	Coeff^a	95% CI	𝑃
BMI	0.07	(−0.07, 0.21)	.30	−0.003	(−0.14, 0.13)	.96
WHR	0.003	(−0.14, 0.15)	.97	−0.03	(−0.17, 0.11)	.67
Waist circumference	0.09	(−0.05, 0.23)	.21	−0.03	(−0.17, 0.11)	.65
Weight	0.15	(0.01, 0.29)	.03	0.02	(−0.12, 0.16)	.77
Hip circumference	0.11	(−0.03, 0.25)	.12	−0.006	(−0.14, 0.13)	.93
Body fat	0.06	(−0.08, 0.20)	.37	−0.05	(−0.19, 0.09)	.47

BMI: body mass index; WHR: waist-hip ratio.
^aCoefficients represent differences in age, sex adjusted SD scores per minor allele in urban compared to rural dwellers.