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Journal of Obesity
Volume 2011 (2011), Article ID 431985, 14 pages
Review Article

Anti-Inflammatory Nutrition as a Pharmacological Approach to Treat Obesity

1Inflammation Research Foundation, Marblehead, MA 01945, USA
2Diabetes Research Institute, University of Miami, Miami, FL 33316, USA

Received 5 May 2010; Accepted 17 August 2010

Academic Editor: A. Halpern

Copyright © 2011 Barry Sears and Camillo Ricordi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity is a multifactorial condition resulting from improper balances of hormones and gene expression induced by the diet. Obesity also has a strong inflammatory component that can be driven by diet-induced increases in arachidonic acid. The purpose of this paper is to discuss the molecular targets that can be addressed by anti-inflammatory nutrition. These molecular targets range from reduction of proinflammatory eicosanoids to the modulation of features of the innate immune system, such as toll-like receptors and gene transcription factors. From knowledge of the impact of these dietary nutrients on these various molecular targets, it becomes possible to develop a general outline of an anti-inflammatory diet that can offer a unique synergism with more traditional pharmacological approaches in treating obesity and its associated comorbidities.